Albert Wyrick Scholar
Gliomas are aggressive brain tumors. Gliomas are very heterogeneous, which is a big problem for treatment. Traditionally, researchers have profiled pieces of tumor with a lot of cells all mixed together, thus masking many information differences. To precisely define brain tumors, I propose to use single cell sequencing techniques directly in patient samples. My laboratory is a leader in these techniques and has shown the potential of these approaches in cancer. I thus propose to: (aim1) perform single cell analyses in brain tumors in adults and children. I also propose (aim2) to use our new data to identify novel ways to target specific programs in brain tumors. Our research will provide the community with a very detailed view of gliomas and suggest ways to improve the treatment of patients.