Research

The V Foundation Grants 2011-Present

GRANTS AWARDED

V Scholar
2011 2012 2013 2014

Designated
2011 2012 2013  2014

Translational
2011 2012 2013 2014

2014 GRANTS


2014 V Scholar Grants

Ash A. Alizadeh, M.D., Ph.D.
Stanford Cancer Center
Palo Alto, CA
Martin D. Abeloff, M.D. V Scholar*
Non-invasive Detection and Monitoring of Tumors and Body Fluids

*The research project that receives the highest rating by the Scientific Advisory Board will annually be designated as the Martin D. Abeloff, M.D. V Scholar.

Kenneth D. Westover, M.D., Ph.D.
University of Texas Southwestern Medical Center
Dallas, TX
Allbert Wryick V Scholar
Development of Irreversible GTPase Active Site Inhibitors for Cancer Therapy
Funded by The Michael and Carole Marks Family

Omar Abdel-Wahab, M.D.
Memorial Sloan-Kettering Cancer Center
New York, NY
Understanding and Targeting Spliceosomal Mutations in Leukemia

Mazhar Adli, Ph.D.
University of Virginia Cancer Center
Charlottesville, VA
Epigenetic Engineering to Correct an Aberrantly Regulated Locus in Cancer

Kara Bernstein, Ph.D.
University of Pittsburgh Cancer Institute
Pittsburgh, PA
Uncovering how Mutations in the RAD51 Paralogues Contribute to Cancer Predisposition and Response to Therapy
2014 V Foundation Wine Celebration Volunteer Grant in Honor of John and Lily Kogan

Ben Croker, Ph.D.
Boston Children’s Hospital
Boston, MA
Accelerating Hematopoietic Recovery after Chemotherapy and Bone Marrow Transplantation
Funded by 2014 Dick Vitale Gala

Emily Dykhuizen, Ph.D.
Purdue University Center for Cancer Research
West Lafayette, IN
The Role of the Bromodomains of PBRM1, a Tumor Suppressive Subunit of the
P-BAF Chromatin Remodeling Complex

Angela Fleischman, M.D., Ph.D.
University of CA, Irvine
Irvine, CA
Pathogenesis of Calreticulin-Mutated Myeloproliferative Neoplasm

Wenjun Guo, Ph.D.
Albert Einstein College of Medicine
Bronx, NY
Role of Novel Breast Cancer Mutations in Cell Fate dysregulation and Oncogenesis

Mohit Jain, M.D., Ph.D.
University of CA, San Diego
San Diego, CA
Systematic Discovery of Metabolic Vulnerabilities in Cancer
Funded by the 2014 Wine Celebration in Honor of David Reynolds and Colleen Buckley

Randall J. Kimple,. M.D., Ph.D.
University of Wisconsin Carbone Cancer Center
Madison, WI
Unmasking the Role of HPV in Modulating Tumor Behavior and Therapy Response

Andrew A. Lane, M.D., Ph.D.
Dana-Farber Cancer Institute
Boston, MA
Defining the Contribution of Chromosome X to Gender-specific Cancer Presdisposition

Megan McNerny, M.D., Ph.D.
The University of Chicago Medicine Comprehensive Cancer Center
Chicago, IL
Transcriptional Misregulation in High-risk Myeloid Neoplasms

Chad V. Pecot, M.D.
The University of North Carolina at Chapel Hill
Lineberger Comprehensive Cancer Center
Chapel Hill, NC
Tumor Angiogenesis Regulation by the miR-200 Family

Karen Sandell Sfanos, Ph.D.
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, MD
Alterations in Urinary Tract Microbiome as a Risk Factor for Prostate Cancer

Agnel Sfeir, Ph.D.
New York University Langone Medical Center
New York, NY
Targeting Polymerase Theta Mediated Double-Strand Break (DSB)

Ruoning Wang, Ph.D.
Nationwide Children’s Hospital
Columbus, OH
Metabolic Reprogramming and modulation of Adaptive Immunity in Tumour Microenvironment
Funded by 2014 Dick Vitale Gala in Memory of Eddie Livingston

John S. Welch, M.D., Ph.D.
Siteman Cancer Center
Washington University in St. Louis
St. Louis, MO
STAG2 Mutations in Leukemia, Hematopoietic Differentiation and Chromatin Structure
Funded by The Hearst Foundation

Omer Yilmaz, M.D., Ph.D.
Koch Institute for Integrated Cancer Research at Massachusetts Institue of Technology
Boston, MA
The Mammalian Stem Cell Niche in Cancer
Funded by Delta Chi Fraternity

Weizhou Zhang, Ph.D.
University of Iowa
Holden Comprehensive Cancer Center
Iowa City, IA
Metformin and Nlrc4-inflammasome in obesity-associated cancer progression

2014 Designated Grants

Damon Reed, M.D.
H. Lee Moffitt Cancer Center and Research Institute
Tampa, FL
Rapid Screening of FDA Approved Chemotherapy Agents to Develop Combinatorial Treatment Regimens for Pediatric Sarcoma
Funded by 2013 Dick Vitale Gala

Paul J. Hergenrother, Ph.D.
University of Illinois Cancer Center
Chicago, IL
PAC-1 for the Treatment of Breast Cancer
Funded by UNDEFEATED Chicago in honor of the Chicago Blackhawks and Darlene Shaw

Hyman B. Muss, MD
UNC Lineberger Cancer Center
Chapel Hill, NC
Impact of Physical Activity on Biomarkers of Aging and Body Composition among Breast Cancer Survivors Age 65 and Older
Funded by The Kay Yow Cancer Fund

Dineo Khabele, MD
Vanderbilt University Medical Center
Nashville, TN
Imaging Ovarian Cancer with Novel Small Molecule Radiotracers of Cyclooxygenase-1
Funded by The Kay Yow Cancer Fund

Parveen Bhatti, Ph.D.
Fred Hutchinson Cancer Center
Seattle, WA
Sleep Disruption and Oxidative Damage among Shift Workers
Funded by Medifast, Inc.

John Cavanagh, Ph.D.
NC State University Cancer Therapeutic Training Program
Raleigh, NC
Developing New Cancer Chemotherapeutics: New Screening Protocols

Steven Dubois, M.D.
UCSF Benioff’s Children’s Hospital
San Francisco, CA
Predictors of Response to IGF-R Inhibition in Metastatic Ewings Sarcoma
Funded in partnership with Quad W

Helene Furberg, Ph.D., M.D.
Vijai Joseph, Ph.D.
Memorial Sloan-Kettering Cancer Institute
New York, NY
The role of germline genetic variation in host response and vascular toxicity from systemic chemotherapy for advanced urothelial cancer
Funded by 2014 Wine Celebration Fund-a-Need

Calvin Lee, Ph.D.
All Children’s Hospital
Tampa Bay, FL
Polycomb group protein control on micro-RNA expression in rhabdomyosarcoma
Funded by Tampa Bay Lightning Foundation

Hui Li, Ph.D.
University of Virginia
Charlottesville, VA
Gene Fusions in Rhabdomyosarcoma
Co-Funded with St. Baldrick’s Foundation

Qing Li, M.D., Ph.D.
University of Michigan
Ann Arbor, MI
Nras signaling in hematopoietic stem cells and leukemic stem cells

David J. McConkey, Ph.D.
Colin P.N. Dinney, M.D.
University of Texas MD Anderson Cancer Institute
Houston, TX
Defining the biological and clinical properties of the p53-like/luminal A subtype of bladder cancer
Funded by 2014 Wine Celebration Fund-a-Need

Mo Motamedi, Ph.D.
Massachusetts General Hospital
Boston, MA
The role of Sirtuins in epigenetics and genomic stability

Sabine Mueller, M.D., Ph.D. UCSF
Benoiff Children’s Hospital
San Francisco, CA
Pediatric Diffuse Instrinsic Pontine Gliomas (DIPGs): Developing a Precision Medicine Approach for Children with DIPG
Vintner Grant in Memory of Shunsuke Yamamoto

Pepper Schedin, Ph.D.
Oregon Health and Science University
Portland, OR
NSAIDS to prevent metastasis of young women’s breast cancer
Funded by The Kay Yow Cancer Fund

Judy Villablanca, M.D.
Children’s Hospital of Los Angeles
Los Angeles, CA
New approaches to neuroblastoma Therapy (NANT) Consortium
Co-funded with Carousel of Possible Dreams/Friends of Cathryn and The 2014 Dick Vitale Gala

Jessie Villanueva, Ph.D.
The Wistar Institute
Philadelphia, PA
Interrogating the Role of S6K as a Molecular Target in Melanoma
The V Foundation –MRA Young Investigator Award
Co-funded with The Melanoma Research Alliance

2014 Translational Grants

Scott Antonia, M.D., Ph.D.
Amer Berg, Ph.D.
Dung-Tsa Chen, Ph.D.
Moffitt Cancer Center
Tampa, FL
A Randomized Phase II Study of a Mesothelin Vaccine in Combination with an Anti-PD-1 Monoclonal Antibody and Chemotherapy in Advanced Lung Adenocarcinoma Patients

Nabeel Bardeesy, Ph.D.
Cyril Benes, Ph.D.
Andrew Zhu, M.D., Ph.D.
Massachusetts General Hospital Cancer Center
Harvard Medical School
Boston, MA
Novel Therapies for Intrahepatic Cholangiocarcinoma

Julie E. Bauman, M.D., Ph.D.
Jennifer Grandis, M.D.
Michelle Ozbun, Ph.D.
University of Pittsburgh Cancer Institute
Pittsburgh, PA
Genetic Alterations of PIK3CA Identify Actionable Targets for HPV-Associated Head and Neck Cancer

Selina Chen-Kiang, Ph.D.
Lewis C. Cantley, Ph.D.
John Leonard, M.D.
Peter Martin, M.D.
Maurizio DiLiberto, Ph.D.
New York-Presbyterian Hospital – Weill Cornell Medical Center
New York, NY
Cell Cycle Sensitization to PI3K therapy in Lymphoma

David Cheresh, Ph.D.
Razelle Kurzrock, M.D.
Karen Messer, Ph.D.
Hatim Husain, M.D.
University of California, San Diego
Moores Cancer Center
San Diego, CA
Integrin avB3 as a CTC Biomarker and Therapeutic Target for Erlotinib-Resistant Lung Cancer

Michael Deininger, M.D., Ph.D.
Thomas O’Hare, Ph.D.
University of Utah – Huntsman Cancer Institute
Salt Lake City, UT
Pathway-Informed Targeted Therapy in Chronic Myelomonocytic Leukemia

Andrew Feinberg, M.D., MPH
Philip Cole, M.D., Ph.D.
Johns Hopkins Medicine
The Sidney Kimmel Comprehensive Cancer Center
Baltimore, MD
Epigenetic Detection and Chemoprevention of Skin Cancer

Michael C. Heinrich, M.D.
Oregon Health & Science University
Portland, OR
Combinaytion Therapy for KIT-mutant Cancer: an Integrated Systems Biology Approach

Darrell J. Irvine, Ph.D.
Masschusetts Institute of Technology
Koch Institute for Integrative Cancer Research
Cambridge, MA
Lymph Node Targeted Patient-Specific Vaccines

Michael B. Major, Ph.D.
D. Neil Hayes, M.D., MPH
Gary Johnson, Ph.D.
The University of North Carolina at Chapel Hill
Lineberger Comprehensive Cancer Center
Chapel Hill, NC
Global Kinase Activity Profiling for Improved Patient Stratification and Response to Targeted Therapy

Wendy Stock, M.A., M.D.
Yusuke Nakamura, M.D., Ph.D.
Olatoyosi Odenike, M.D.
The University of Chicago Medicine
Comprehensive Cancer Center
Chicago, IL
TOPK (T-LAK cell-originated protein Kinase): A new target for FLT3 mutated AML

David J. Tweardy, M.D.
Michael T. Lewis, Ph.D.
Mothaffar F. Rimawi, M.D.
Baylor College of Medicine
Dan L. Duncan Cancer Center
Houston, TX
Oral small Molecular Stat3 Inhibitor to Treat Breast Cancer

2013 GRANTS

2013 V Scholar Grants

Bjoern Schwer, M.D., Ph.D.
Boston Children’s Hospital
Boston, MA
Martin D. Abeloff, M.D. V Scholar*
Neural Genome Rearrangements and Alternative end Joining Processes in Initiation and Maintenance of Medulloblastoma

*The research project that receives the highest rating by the Scientific Advisory Board will annually be designated as the Martin D. Abeloff, M.D. V Scholar.

Maximilian Diehn, M.D., Ph.D.
Stanford Cancer Institute
Stanford, CA
Albert Wyrick V Scholar Award
Investigating the KEAP1-NRF2 Pathway in Lung Stem Cells and Lung Cancer
Funded by The Michael and Carole Marks Family

Rafael Bejar, M.D., Ph.D.
UCSD Moores Cancer Center
La Jolla, CA
Pathogenic Mechanisms of Splicing Factor Mutations in Myelodysplastic Syndromes

Timothy F. Burns, M.D., Ph.D.
University of Pittsburgh Cancer Institute
Pittsburgh, PA
Targeting KRAS Mutant Lung Adenocarcinoma through Inhibition of TWIST 1
Supported by UNICO National in Memory of Sue Speciale

Luis Carvajal-Carmona, Ph.D.
University of California, Davis
Sacramento, CA
Identification of Novel Breast Cancer Genes in a Hispanic Isolate

Robert Doebele, M.D., Ph.D.
University of Colorado School of Medicine
Department of Medicine, Division of Medical Oncology
Aurora, CO
NTRK1 Gene Fusions as a Novel Oncogene Class and Therapeutic Target in Lung Cancer
Funded in Memory of Calvin Bradham with support from Crown Imports

Michael J. Emanuele, Ph.D.
Lineberger Comprehensive Cancer Center
University of North Carolina at Chapel Hill
Chapel Hill, NC
Identification of Ubiquitin Signaling Networks as Novel Avenues for Therapeutic Intervention

Summer Gibbs, Ph.D.
Oregon Health & Science University
Portland, OR
Screening of Small Molecule Fluorophores to Probe Pancreatic Cancer Margins in the Operating Room

Peter Hammerman, M.D., Ph.D.
Dana-Farber Cancer Institute
Boston, MA
Targeting Fibroblast Growth Factor Receptor Fusions in Lung and Head and Neck Cancer

Mei Kong, Ph.D.
Beckman Research Institute of the City of Hope
Duarte, CA
Targeting Glutamine Metabolism and the B55a-p53 Survival Pathway for Lymphoma Treatment

Christopher A. Maher, Ph.D.
Siteman Cancer Center
Washington University
St. Louis, MO
2013 Vintner Grant – Funded by The Wine Celebration
In Honor of Fred and Mary Constant, Jeff and Valerie Gargiulo, Dick and Ann Grace, Fred and Sally Schweiger, and Lowell and Janet Herrero
Understanding the Role of Polycomb Associated LncRNAs in Prostate Cancer

Michael Kharas, Ph.D.
Memorial Sloan-Kettering Cancer Center
New York, NY
Understanding the MSI2 RNA Binding Protein Network in Leukemia

George-Lucian Moldovan, Ph.D.
Penn State Hershey Cancer Institute
Hershey, PA
Dysregulation of the PARI Genomic Stability Pathway in Leukemia

Zeshaan Rasheed, M.D., Ph.D.
The Sidney Kimmel Comprehensive Cancer Center
Baltimore, MD
Regulatory Effects of the Tumor Microenvironment on Stem Cell Plasticity in Pancreatic Ductal Adenocarcinoma

Jatin Roper, M.D.
Tufts Medical Center
Boston, MA
The Role of IWS1 and FGFR2 Isoform IIIc in Akt Isoform-dependent Colorectal Carcinogenesis

Ryan A. Wilcox, M.D., Ph.D.
University of Michigan Comprehensive Cancer Center
Ann Arbor, MI
Role of the T-cell Transcription Factor GATA-3 in Cutaneous T-cell Lymphomas

Kris C. Wood, Ph.D.
Duke Cancer Institute
Durham, NC
Systematic Identification of Combination Therapies Targeting the Breast Cancer Microenvironment
2013 V Foundation Wine Celebration Vounteer Grant in Honor of John and Anne Sachs

Chunling Yi, Ph.D.
Lombardi Comprehensive Cancer Center
Georgetown University
Washington, DC
Interrogating the Role of Hippo-Yap Growth Regulatory Pathway in Kidney Cancer

2013 Designated Grants

Lizi Wu, Ph.D.
Shands Cancer Center
University of Florida
Gainesville, FL
Funded by 2012 Dick Vitale Gala
In Memory of Caleb Gacobbe
Regulation of Oncogenic NOTCH Signaling in Childhood Leukemia

Daniel S. Wechsler, M.D., Ph.D.
Duke University Medical Center
Durham, NC
Funded by The Apple Gold Group
Therapeutic Targeting of Calm-AF10 Nuclear Export in Pediatric Leukemia

Stuart Goldberg, M.D.
Hackensack University Medical Center
The John Theurer Cancer Center
Hackensack, NJ
Funded by Marketing Research Consultants
In Memory of Mary Ann Ingoglia
The Use of Dynamic Single Cell Network Profile to Predict Outcome in Newly Diagnosed Acute Myelogenous Leukemia (AML)

Victoria Belancio, Ph.D.
Tulane University
Tulane Cancer Center
New Orleans, LA
Funded by The Kay Yow Cancer Fund
Line-1 Contributing to Lung Cancer in Vivo

Shari Pilon-Thomas, Ph.D.
William E. Janssen, M.D.
H. Lee Moffitt Cancer Center & Research Institute
Tampa, FL
Funded by 2012 Dick Vitale Gala
In memory of Dave Heard
Adoptive Cell Therapy for Neuroblastoma

Amit K. Verma, M.D.
David J. Prezant, M.D.
Mayris Webber, M.P.H., Dr. P.H.
Charles B. Hall, Ph.D.
Albert Einstein College of Medicine of Yeshiva University
Bronx, NY
Funded by 2012 The V Foundation Wine Celebration and Jimmy V Celebrity Golf Classic
Early Detection of Hematologic Malignancies in New York City Firefighters Exposed to World Trade Center Dust after the 9/11 Attacks

Queen of the Valley Medical Center
Napa, CA
Funded by The V Foundation Wine Celebration
Clinical Laboratory and Pathology Services
Herman Family Advanced Diagnostic and Surgical Services Pavilion

St. Helena Hospital
Napa, CA
Funded by The V Foundation Wine Celebration
Clinical Research Program at St. Helena Hospital Martin-O’Neil Cancer Center

Calvin Lee, M.D.
All Children’s Hospital
St. Petersburg, FL
Funded by 2013 Dick Vitale Gala
BMI1’s Role in the Regulation of Myogenic Differentiation in Rhabdomyosarcoma

John Cavanagh, Ph.D.
North Carolina State Jimmy V Cancer Therapeutics Program
Raleigh, NC
Funded by 2013 Jimmy V Celebrity Golf Classic and The V Foundation
In Honor of the JVCGC 20 Year Volunteers
Developing New Cancer Chemotherapeutics

James M. Ford, M.D.
Stanford University School of Medicine
Stanford, CA
Funded by The Gastric Cancer Foundation
Gastric Cancer Genomic Research

Daniel S. Wechsler, M.D., Ph.D.
Catherine P. Lavau, DVM, Ph.D.
Duke University Medical Center
Durham, NC
Funded by The Apple Gold Group
A Novel Role for the CRM1 Nuclear Export Receptor in Leukemogenesis:  Mechanisms and Targeting

2013 Translational Grants

Nika Danial, Ph.D.
Margaret Shipp, M.D.
Jarrod Marto, Ph.D.
Dana-Farber Cancer Institute
Boston, MA
Fueling DLBCL Proliferation and Survival:  A Role for Fatty Acid Metabolism

Ralph Deberardinis, M.D., Ph.D.
Kemp Kernstein, M.D., Ph.D.
Children’s Medical Center Research Institute at Universtiy of Texas Southwestern
Dallas, TX
Funded in Memory of Christopher T. Carroll
Translational Studies in Lung Cancer Metabolism:  Creating New Paradigms in Diagnosis and Therapy

Gianpietro Dotti, M.D.
Cliona Rooney, Ph.D.
Caridad Martinez, M.D.
Dan L. Duncan Cancer Center at Baylor College of Medicine
Houston, TX
Prevention and Treatment of Viral Infections and Leukemic Relapse after Allogeneic Stem Cell Transplantation

Benjamin L. Ebert, M.D., Ph.D.
Ann Mullally, M.D.
William Kaelin, Jr., M.D.
David Steensma, M.D.
Brigham and Women’s Hospital
Boston, MA
Identifying and Targeting Oncogenic Pathways in TET2 and IDH Mutant Myeloid Malignancies

Tanja A. Gruber, M.D., Ph.D.
James R. Downing, M.D.
St. Jude Children’s Research Hospital
Memphis, TN
Funded by the 2013 Dick Vitale Gala in Honor of Dick and Lorraine Vitale
Identification of  Active Compounds in Infantile Acute Lymphoblastic Leukemia 

John V. Heymach, M.D., Ph.D.
Varsha Gandhi, Ph.D.
Christine Stellrecht, Ph.D.
Carlo Toniatti, M.D., Ph.D.
Timothy Heffernan, Ph.D.
The University of Texas MD Anderson Cancer Center
Houston, TX
Attacking the Specific Vulnerability of LKB1-Mutant NSCLC to Energy Depletion Using an ATP Mimetic

Ite A.Laird-Offringa, Ph.D.
Barbara Gitlitz, M.D.
Martin W. Kast, Ph.D.
Kimberly Siegmund, Ph.D.
Lina Wang, M.D.
Michael Wong, M.D., Ph.D.
USC Norris Comprehensive Cancer Center
Los Angeles, CA
Development of Immunotherapy for Small Cell Lung Cancer using Novel Modified Antigens

Daniela Matei, M.D.
Kenneth P. Nephew, Ph.D.
Indiana University Melvin and Bren Simon Cancer Center
Indianapolis, IN
An Epigenetic Strategy for Restoring Carboplatin Sensitivity in Ovarian Cancer

Toshi Tanuiguchi, M.D., Ph.D.
Elizabeth M. Swisher, M.D.
Fred Hutchinson Cancer Center
Seattle, WA
Defining Genomic Scarring and Functional DNA Variants that Predict Response to PARP Inhibitors in a Clinical Trial for Recurrent Ovarian Cancer 

Pengbo Zhou, Ph.D.
Leonard Salta, M.D.
Yao-Tseng Chen, M.D., Ph.D.
Weill Cornell Medical College
New York, NY
Funded by The V Foundation Wine Celebration
In Honor of Steve Bornstein
Ubiquitin Ligase as a Novel Diagnostic Marker and Therapeutic Target for Colorectal Cancer

 

2012 GRANTS

2012 V Scholar Grants

Monte M. Winslow, Ph.D.
Stanford Cancer Institute
Stanford University
Stanford, CA
Martin D. Abeoff, M.D. V Scholar Award*
Functional characterization of Nkx2-1 regulated genes that govern lung cancer metastasis

*The research project that receives the highest rating by the Scientific Advisory Board will annually be designated as the Martin D. Abeloff, M.D. V Scholar Award.

Justin D. Lathia, Ph.D.
Cleveland Clinic Lerner College of Medicine
Cleveland, OH
Albert Wyrick V Scholar Award
Funded by the Michael and Carole Marks Family 
Holding on to stemness: targeting mechanisms that maintain glioblastoma stem cells

Hiu Wing Cheung, Ph.D.
Hollings Cancer Center
Medical University of South Carolina
Charleston, SC
Role of ID4 in ovarian cancer development and metastasis

Christina Curtis, Ph.D.
USC Norris Comprehensive Cancer Center
University of Southern California
Los Angeles, CA
Interrogating patient-specific tumor dynamics through single cell profiles and computational modeling

Todd Fehniger, M.D., Ph.D.
Siteman Cancer Center
Washington University School of Medicine
St. Louis, MO
Enhanced Innate Immunity to Cancer Utilizing Human Memory-like NK cells

Daniel A. Harki, Ph.D.
Masonic Cancer Center
University of Minnesota
Minneapolis, MN
Funded by Delta Chi Fraternity 
Beyond Parthenolide: Next Generation Molecules Targeting AML Cancer Stem Cells

Qing Li, M.D., Ph.D.
University of Michigan Comprehensive Cancer Center
University of Michigan
Ann Arbor, MI
NRAS signaling in hematopoietic stem cells and leukemic stem cells

Unhee Lim, Ph.D.
University of Hawaii Cancer Center
University of Hawaii
Honolulu, HI
Investigating Global Leukocyte DNA Methylation for Predicting Colorectal Cancer Risk in a Multiethnic Population

Mohammad (Mo) Motamedi, Ph.D.
Massachusetts General Hospital Cancer Center
Charlestown, MA
The role of Sirtuins in epigenetics and genomic stability

Trudy G. Oliver, Ph.D.
Huntsman Cancer Institute
University of Utah
Salt Lake City, UT
Funded by the Thomas Carroll Family
In memory of Christopher T. Carroll
Understanding Myc’s role in Small Cell Lung Cancer

Asha Bhaskaran Pillai, M.D.
St. Jude Children’s Research Hospital
Memphis, TN
Funded in part by UNICO in memory of John Gristani
Augmenting Cytotoxicity of Ex vivo Expanded Human iNKT cells for Cancer Immunotherapy

Jeffrey W. Tyner, Ph.D.
Knight Cancer Institute
Oregon Health and Science University
Portland, OR
Translation of Novel Mutations in CSF3R into Validated Therapeutic Modalities

Christopher R. Vakoc, M.D., Ph.D.
Cold Spring Harbor Laboratory
Cold Spring Harbory, NY
Therapeutic targeting of the Polycomb Complex PRC2 in acute myeloid leukemia

Jeffrey Venstrom, M.D.
UCSF Helen Diller Family Comprehensive Cancer Center
University of California at San Francisco
San Francisco, CA
Funded by The V Foundation Wine Celebration Volunteer Grant
In honor of Derek and Cathy Reisinger
Mechanisms and strategies for recruiting natural killer cells to cure acute myeloid leukemia

Jessie Villanueva, Ph.D.
The Wistar Institute
Philadelphia, PA
Establishing molecular targets for NRAS driven melanomas: an unmet medical need

Sarah (Sadie) Wignall, Ph.D.
Robert H. Lurie Comprehensive Cancer Center
Northwestern University
Chicago, IL
Targeting centrosome-clustering mechanisms to selectively kill cancer cells

Xiaoyang Wu, Ph.D.
University of Chicago Comprehensive Cancer Institute
University of Chicago
Chicago, IL
Spectraplakin and coordinated cytoskeletal dynamics in colorectal cancer

2012 Designated Grants

Ramaswamy Govindan, M.D.
Siteman Cancer Center
Washington University School of Medicine
St. Louis, MO
Funded by UNICO
In memory of Dorothy Jean Varsalona
Molecular Assay to Predict Outcomes in Resected NSCLC using Nanostring Technology

Steven Zeitels, M.D., FACS
Massachusetts General Hospital Cancer Center
Boston, MA
Funded by the Dick Vitale Gala
Voice Preservation in the Treatment of Early Glottic (Laryngeal) Cancer

Hai Yan, M.D., Ph.D.
Duke Cancer Institute
Duke University Medical Center
Durham, NC
Supplemental SPORE
Funded by The V Foundation Wine Celebration and Accelerate Brain Cancer Cure
Developing Novel Approaches to Target Gliomas

Susan Goodin, PharmD.
Cancer Institute of New Jersey
Robert Wood Johnson Medical School
New Brunswick, NJ
Funded by Marketing Research Consultants 
Prevention of Prostate Cancer progression by atorvastatin and celecoxib

Peter Forsyth, M.D.
H. Lee Moffitt Cancer Center and Research Institute
University of South Florida
Tampa, FL
Funded by the Dick Vitale Gala
Developing Myxoma Virus as an Experimental Treatment for Brain Cancer Stem Cells in Children and Adults with Malignant Gliomas

University of Texas MD Anderson Cancer Center
University of Texas
Houston, TX
SPORE in Ovarian Cancer
Funded by the Kay Yow Cancer Fund

Corrine Linardic, M.D., Ph.D.
Duke Cancer Institute
Duke University Medical Center
Durham, NC
Funded by Apple Gold Group
Understanding SFRP’s contribution to alveolar rhabdomyosarcoma tumorigenesis

Daniel S. Wechsler, M.D., Ph.D.
Duke Cancer Institute
Duke University Medical Center
Durham, NC
Funded by Apple Gold Group
Strike While the Iron is Not:  Targeting CALM-Rearranged Leukemias by Iron Deprivation

St. Helena Hospital Foundation
St. Helena, CA
Funded by The V Foundation Wine Celebration
Caring for the Future

Victoria F. Borges, M.D., MMSc
University of Colorado Cancer Center
University of Colorado
Denver, CO
Funded by the Kay Yow Cancer Fund
Pilot Study the Prevention of Postpartum Pregnancy Associated Breast Cancer

Nehal Parikh, M.D.
Connecticut Children’s Medical Center
Hartford, CT
Funded by ESPN, Inc.
Isolation and Characterization of Cancer Stem Cells in Neuroblastoma Tumor Model 

All Children’s Hospital
Dick Vitale Pediatric Cancer Research Fellowship
St. Petersburg, FL
Funded by the Dick Vitale Gala

James M. Ford, M.D.
Stanford Cancer Institute
Stanford University
Palo Alto, CA
Funded by the Gastric Cancer Foundation

MD Anderson Cancer Center
Pediatric Cancer
Funded by LG Electronics Home Court Advantage

Angela M. Hartley Brodie, Ph.D.
University of Maryland School of Medicine
Funded by Friends of V Baltimore Golf Classic
Targeting Mechanisms of Resistance to Hormone Therapy in Breast Cancer

Ian Davis, M.D., Ph.D.
UNC Lineberger Comprehensive Cancer Center
University of North Carolina at Chapel Hill
Chapel Hill, NC
Funded by the Jimmy V Celebrity Golf Classic
Targeting Deregulated Transcription in Pediatric Cancers

2012 Translational Grants

Steven P. Balk, M.D., Ph.D.
Huihui Ye, MMSc.
Glenn Bubley, M.D.
Martin Sanda, M.D.
Beth Israel Deaconess Medical Center
Boston, MA
Molecular characterization of Gleason 3 tumors that progress to Gleason 4

Nora Heisterkamp, Ph.D.
Steven Mittelman, M.D., Ph.D.
Yong-mi Kim, M.D., Ph.D.
Children’s Hospital Los Angeles
Los Angeles, CA
Improving treatment outcome in leukemia by disruption of bone-marrow leukemia interactions relevant to minimal residual disease

Kimberly Stegmaier, M.D.
James E. Bradner, M.D.
Lisa R. Diller, M.D.
Dana-Farber Cancer Institute
Boston, MA
Therapeutic targeting of N-Myc with BET Bromodomain Inhibition in Neuroblastoma

Mark C. Lanasa, M.D., Ph.D.
Sandeep Dave, M.D., M.S.
Duke Cancer Institute
Duke University Medical Center
Durham, NC
Genetic determinants of progression in chronic lymphocytic leukemia

Martine F. Roussel, Ph.D.
Amar Gajjar, M.D.
St. Jude Children’s Research Hospital
Memphis, TN
Identification and pre-clinical testing of compounds to treat Group 3 medulloblastoma

Anthony E. Oro, M.D., Ph.D.
Jean Y. Tang, M.D., Ph.D.
Stanford Cancer Institute
Stanford University
Stanford, CA
Novel Therapies for Hedgehog-dependent cancers

Miaofen G. Hu, M.D., Ph.D.
Richard Van Eten, M.D., Ph.D.
Tufts Medical Center
Medford, MA
CDK6 as a novel therapeutic target in T-cell Acute Lymphoblastic Leukemia

Michele Carbone, M.D., Ph.D.
Haining Yang, Ph.D.
Ian Pagano, Ph.D.
University of Hawaii Cancer Center
University of Hawaii
Honolulu, HI
HMGB1: A Biomarker for Mineral Fiber Exposure and Detection of Malignant Mesothelioma

Reuben S. Harris, Ph.D.
Douglas Yee, M.D.
Masonic Cancer Center
University of Minnesota
Minneapolis, MN
Funded by The V Foundation Wine Celebration Vintner Grant
In honor of Suzanne Pride-Bryan
Role of DNA Deamination in Breast Cancer

W. Kimryn Rathmell, M.D., Ph.D.
Jason Lieb, Ph.D.
Ian Davis, M.D., Ph.D.
UNC Lineberger Comprehensive Cancer Center
University of North Carolina at Chapel Hill
Chapel Hill, NC
Funded by the Jimmy V Celebrity Golf Classic
In memory of Girard Tillery
Reprogramming the Histone Methylation Code of Renal Cell Carcinoma

2011 GRANTS

2011 V Scholar Grants

Gang (Greg) Wang, Ph.D.
UNC Lineberger Comprehensive Cancer Center
University of North Carolina at Chapel Hill
Chapel Hill, NC
Martin D. Abeloff, M.D. V Scholar Award*
Cancer Epigenetics:  Understanding Histone Methylation in Hematopoietic Malignancies

Hongwu Zheng, Ph.D.
Cold Spring Harbor Laboratory
Cold Spring Harbor, NY
Martin D. Abeloff, M.D. V Scholar Award*
Genetic and functional characterization of EGFR-targeted therapy resistance in malignant gliomas

*The research project that receives the highest rating by the Scientific Advisory Board will annually be designated as the Martin D. Abeloff, M.D. V Scholar Award.  This year we had two projects tied with the highest rating.

David Barbie, M.D.
Dana-Farber Cancer Institute
Boston, MA
Albert Wyrick V Scholar Award
Funded by Michael and Carole Marks
Targeted Therapy Development for KRAS-Driven Lung Cancers

Denise A. Chan, Ph.D.
UCSF Helen Diller Comprehensive Cancer Center
University of California at San Francisco
San Francisco, CA
Defining the molecular mechanisms of metastasis and tumor recurrence following radiation therapy

Keith Syson Chan, Ph.D.
Dan L. Duncan Cancer Center
Baylor College of Medicine
Houston, TX
Funded by the Jimmy V Celebrity Golf Classic Volunteer Award
In honor of Dave Gibson and Felicia Davis
Investigate the interplay between cellular differentiation status and oncogene-induced cancer phenotype

John T. Chang, M.D.
UC San Diego Moores Cancer Center
University of California San Diego
La Jolla, CA
Modulating Polarity to Enhance CD8+ T Cell Immune Responses against Cancer

David Glenn DeNardo, Ph.D.
Siteman Cancer Center
Washington University School of Medicine
St. Louis, MO
Immune Regulation of the Cancer Stem Cell Niche

Geraldine J. Guasch, Ph.D.
Cincinnati Children’s Hospital Medical Center
Cincinnati, OH
Using a novel mouse model of transitional epithelial tumor to investigate cancer initiation and progression

Nada Y. Kalaany, Ph.D.
Children’s Hospital Boston
Boston, MA
Funded by The V Foundation Wine Celebration Vintner Grant
In honor of Robin Baggett and Michelle Fields
Role of PTEN/P13K pathway in obesity-associated cancer incidence and progression

Joseph W. Landry, Ph.D.
VCU Massey Cancer Center
Virginia Commonwealth University
Richmond, VA
Chromatin Remodeling Complex NURF as Regulator of Cyclin D1 Transcription in Breast Cancer Cells

Tanja Mittag, Ph.D.
St. Jude Children’s Research Hospital
Memphis, TN
Multi-site Recognition of Ubiquitin Ligase Substrates in Signaling and Cancer

Trista E. North, Ph.D.
Beth Israel Deaconess Medical Center
Boston, MA
Characterization of Vitamin D3 as a novel regulator of hematopoietic stem cell homeostasis with therapeutic potential for leukemia treatment

Miles A. Pufall, Ph.D.
Holden Comprehensive Cancer Center
University of Iowa
Iowa City, IA
B-precursor acute lymphoblastic leukemia: Studying the mechanisms behind Dexamethasone and Prednisone sensitivity in high-risk patients

William L. Redmond, Ph.D.
Providence Portland Medical Center
Earle A. Chiles Research Institute
Portland, OR
Elucidate the mechanisms regulating prostate cancer immunotherapy

Zachary T. Schafer, Ph.D.
Harper Cancer Research Institute
University of Notre Dame
Notre Dame, IN
Funded by Hooters of America
In honor of Milly Longmire
The Regulation of Tumor Cell Survival by Carcinoma-Associated Fibroblasts

Qianben Wang, Ph.D.
The Ohio State University Comprehensive Cancer Center
James Cancer Hospital & Solove Research Institute
Ohio State University
Columbus, OH
Targeting aberrant FoxA1-CREB1 signaling in castration-resistant prostate cancer

Bin Zheng, Ph.D.
Herbert Irving Comprehensive Cancer Center
Columbia University Medical Center
New York, NY
Targeting Metabolism in Melanoma

2011 Designated Grants

Gary Hammer, M.D., Ph.D.
University of Michigan Comprehensive Cancer Center
University of Michigan
Ann Arbor, MI
Funded by Hart’s Desire Fundraising Event
Genomic Analyses of Adrenocortical Cancer

Chunyan He, ScD
IU Melvin and Bren Simon Cancer Center
Indiana University
Indianapolis, IN
Funded by the Kay Yow Cancer Fund
Genetic Variants, microRNA Expression and Breast Cancer

Hanlee Ji, M.D.
James M. Ford, M.D.
Stanford Genome Technology Center
Stanford University
Palo Alto, CA
Funded by the Gastric Cancer Fund
Computational Analysis of Gastric Cancer Genomes and Inherited Gastric Cancer

Mark Kester, Ph.D.
Kevin Stavely-O’Carroll, M.D., Ph.D.
Penn State University Cancer Center
Hershey, PA
Funded by UNICO Foundation
In memory of Salvatore Bernardi
Novel Therapeutic Approaches to Gastrointestinal Malignanciesn

St. Helena Hospital
St. Helena, CA
Funded by Caring for the Future

2011 Translational Grants

Suzanne J. Baker, Ph.D. 
Cynthia Wetmore, M.D., Ph.D. 
St. Jude Children’s Research Hospital
Memphis, TN
Targeting PDGFR in Pediatric High-Grade Gliomas

Andrei Thomas-Tikhonenko, Ph.D.
Stephan Grupp, M.D., Ph.D.
Children’s Hospital of Philadelphia Research Institute
Philadelphia, PA
Novel therapeutic targets in acute B-lymphoblastic leukemia

Richard Roden, Ph.D.
Sara Pai, M.D., Ph.D.
TC Wu, M.D., Ph.D.
Sidney Kimmel Comprehensive Cancer Center
Johns Hopkins University
Baltimore, MD
Treatment of Head and Neck cancer with an HPV vaccine

Iannis Aifantis, Ph.D.
Elizabeth A. Raetz, M.D.
New York University Cancer Institute
New York University
New York, NY
Clinical Implications of TET Regulated DNA Methylation in Acute Lymphoblastic Leukemia

Leonard I. Zon, Ph.D.
Richard M. White, M.D.
Children’s Hospital of Boston
Boston, MA
Cell Fate as a Target in Melanoma

Janice M. Mehnert, M.D.
Eileen P. White, Ph.D.
Cancer Institute of New Jersey
Robert Wood Johnson Medical School
New Brunswick, NJ
Examining the Role of Autophagy in Melanoma Tumorigenesis

Faith M. Uckun, M.D., Ph.D.
Paul S. Gaynon, M.D.
Amanda M. Termuhlen, M.D.
Childrens Center for Cancer and Blood Diseases
Children’s Hospital Los Angeles
Los Angeles, CA
Funded by The V Foundation Wine Celebration
Directing Leukemia Cells to Self-Destruct Using Recombinant Human CD19-Ligand:sTrial Fusion Protein

Carlos A. Ramos, M.D.
Ann M. Leen, Ph.D.
Dan L. Duncan Cancer Center
Baylor College of Medicine
Houston, TX
Most Closely HLA-Matched Allogeneic LMP1/2 – Specified Cytotoxic T Lymphocytes for Treatment of Patients with Relapsed Epstein-Barr Virus-Associated Lymphomas

Hua Eleanor Yu, Ph.D.
Stephen J. Forman, M.D.
Marcin Kortylewski, Ph.D.
City of Hope Comprehensive Cancer Center
Beckman Research Institute
Duarte, CA
Funded by The V Foundation Wine Celebration
In honor of Neil Aldoroty
Targeting STAT3 in tumor and the tumor microenvironment by a novel siRNA technology to treat lymphoma