Research

V Foundation Grants 2005-2010

2010 Grants

2010 V Foundation V Scholars

Srinivasan Yegnasubramanian, M.D., Ph.D.
Sidney Kimmel Cancer Center at Johns Hopkins
Baltimore, MD
Martin D. Abeloff, M.D. V Scholar Award
Pre-clinical developmental clinical testing of DNA methylation biomarkers of aggressive prostate cancer

André Hoelz, Ph.D.
California Institute of Technology
Pasadena, CA
Albert Wyrick V Scholar Award
Funded by Michael and Carole Marks
Structural and Functional Analysis of Marcomolecular Machines in Chromatin Biology and Carcinogenesis

Yong Cang, Ph.D.
Sanford-Burnham Medical Research Institute
La Jolla, CA
Investigation of Hepatocarcinogenesis Using a Novel Mouse Model

Mark Chiang, M.D., Ph.D.
University of Michigan Comprehensive Cancer Center
Ann Arbor, MI
The Significance of Tlx1/Hox11 in T-cell acute lymphoblastic leukemia/lymphoma

Benjamin Deneen, Ph.D.
Baylor College of Medicine
Dan L. Duncan Cancer Center
Houston, TX
Delineating the role of Nuclear Factor I-A in the generation of Glioblastoma Multiforme: linking glial fate determination and tumorigenesis

Danica Galonic Fujimori, Ph.D.
The Helen Diller Family Comprehensive Cancer Center
University California, San Francisco
San Francisco, CA
Targeting Epigenetic Mechanisms of Cancer: Elucidating Roles of Jumonji Histone-Demethylasas

Monica Gostissa Ph.D.
Boston Children’s Hospital
Boston, MA
Elucidating Principles of Chromosomal Translocations in B Cells

Monica L. Guzman, Ph.D.
Weill Cornell Medical College
New York, NY
Transcriptional and epigenetic characterization of the drug resistance in acute myelogenous leukemia stem cells

M. Kyle Hadden, Ph.D.
Carole and Ray Neag Comprehensive Cancer Center
University of Connecticut
Farmington, CT
A Chemical Biology Approach to Understanding the Anti-Cancer Effects of Vitamin D3

Hui Li, Ph.D.
University of Virginia Health System
Charlottesville, VA
Role of RNA Trans-splicing in Prostate Cancer
Funded by Delta Chi Fraternity

Don X. Nguyen, Ph.D.
Yale Cancer Center
New Haven, CT
Tumor-microenvironment interactions that regulate the therapeutic response of lung cancer brain metastasis
Funded in memory of Christopher T. Carroll

Vu H. Nguyen, M.D.
The University of Chicago Comprehensive Cancer Center
Chicago, IL
Preserving tumor immunity following hematopoietic stem cell transplantation

Ken-ichi Noma, Ph.D.
The Wistar Institute
Philadelphia, PA
Identification of a novel pathway that facilitates chromosome instability in cancer

Jennifer Rhodes, Ph.D.
Fox Chase Cancer Center
Philadelphia, PA
Dissecting the oncogenic and molecular function of a novel hematopoietic zinc finger factor 

Jorge Torres, Ph.D.
Jonsson Comprehensive Cancer Center
University of California, Los Angeles
Los Angeles, CA
Functional Proteomics in Cell Division and Cancer Therapy 

Hushan Yang, Ph.D.
Kimmel Cancer Center
Thomas Jefferson University
Philadelphia, PA
Predisposition to Hepatocellular Carcinoma in HBV patients – A Multigenic Approach to MicroRNA 

Jing Zhang, Ph.D.
Carbone Cancer Center
University of Wisconsin
Madison, WI
The Role of Endogenous Kras and Nras Signaling in Myeloid Leukemias 

2010 Designated Grants

William Janssen, Ph.D.
Shari Pilon-Thomas, Ph.D.
James J. Mule, Ph.D.
*Gregory Hale, Ph.D.
H. Lee Moffitt Cancer Center
*All Children’s Hospital

Funded by 2010 Dick Vitale Gala
Combined Cell Therapy Approach to the Treatment of Neuroblastoma

Erwin G. Van Meir, Ph.D.
Winship Cancer Institute of Emory University
Atlanta, GA
Accelerating the translation of novel small molecule HIF inhibitors to cancer patient treatment 

Leisha A. Emens, M.D., Ph.D.
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, MD
Facilitating Potent Breast Tumor Immunity by Antibody-Enhanced Vaccination

xxx Funded by Kay Yow/WBCA Foundation

Kentucky Prostate Cancer Coalition
Louisville, KY

M.D. Anderson Cancer Center
Bast/Goodfellow Physician Scientist Endowment
Houston, TX

Steven M. Zeitels, M.D., FACS
Massachusetts General Hospital
Boston, MA
Voice Preservation in the Treatment of Early Glottic (Laryngeal) Cancer
Funded by the 2010 Dick Vitale Gala

Nancy E. Thomas, M.D., Ph.D.
David W. Ollila, M.D.
UNC Lineberger Cancer Center
Chapel Hill, NC
Tumor DNMethylation as a Biomarker for Melanoma
Funded by Jimmy V Celebrity Golf Classic
In Honor of Parker Ellison and Richard Hopkins

Shands Children’s Hospital
University of Florida
Gainesville, FL
Pediatric Bone Marrow Unit

Rajeshwar Rao Tekmal, Ph.D.
University of Texas Health Science Center at San Antonio
San Antonio, TX
Novel Therapeutic Approach to overcome resistance to endocrine therapies of breast cancer
Funded by the Kay Yow Foundation

Gregory Hale, M.D.
*William Janssen, Ph.D.
All Children’s Hospital
*H. Lee Moffitt Cancer Center
St. Petersburg, FL
Cellular Therapies to Treat Children and Adolescents with Refractory Malignancies
Funded by the 2010 Dick Vitale Gala

James M. Ford, M.D.
Stanford University Medical Center
Palo Alto, CA
Gastric Cancer Genetics Research
Funded by the Gastric Cancer Fund

St. Helena Hospital
St. Helena, CA
Caring for the Future Campaign
Funded by the 2009 Wine Celebration 

A. Thomas Look, M.D.
Dana-Farber Cancer Institute
Boston, MA
Pathway Addiction Due to Autocrine Activation of MET Provides a New Therapeutic Target in AML
Funded by The Wine Celebration in Honor of Teri Kuhn

2010 Translational Grants

Mark Alan Rosen, M.D., Ph.D.
William Lee, M.D., Ph.D.
Abramson Cancer Center
University of Pennsylvania
Philadelphia, PA
Use of PET and MR Imaging Biomarkers to Predict Response of Renal Cell Carcinoma to Tyrosine Kinase Inhibitor Therapy

Cory T. Abate-Shen, Ph.D.
Edward Gelmann, M.D.
Herbert Irving Comprehensive Cancer Center
Columbia University
New York, NY
Pre-clinical and clinical appraoches for developing new treatments for castration-resistant prostate cancer 

A. Craig Lockhart, M.D.
Siteman Cancer Center
Washington University
St. Louis, MO
Whole genome sequencing to identify predictive markers and novel therapeutic targets in gastric and gastroesophageal cancers

Amir Goldkorn, M.D.
Parkash Gill, M.D
USC/Norris Comprehensive Cancer Center
Los Angeles, CA
Targeting the Ephrin Pathway:  A Phase 1 Therapeutic Trial with Circulating Tumor Cell Molecular Correlates

Garrett M. Brodeur, M.D.
Robert J. Levy, M.D.
Children’s Hospital of Philadelphia Research Institute
Philadelphia, PA 
Nanoparticle Delivery of TRK Inhibitors in Neuroblastomas

Nancy Lin, M.D.
Kornelia Polyak, M.D., Ph.D.
Dana-Farber Cancer Institute
Boston, MA
Targeting the IL-6/JAK2/Stat3 pathway in human breast cancer

Christopher E. Touloukian, M.D.
Simon Cancer Center
Indiana University
Indianapolis, IN
The Use of Gene-modified Lymphoid Progenitor Cells for Treatment of Patients with Metastatic Melanoma
2010 Wine Celebration Vintner Grant
In Honor of Blakesley and Cyril Chappellet

Derek C. Radisky, Ph.D.
Lynn Hartmann, M.D.
Mayo Clinic Cancer Center
Jacksonville, FL
Lobular Involution and Breast Cancer in Postmenopausal Women

Ignacio I. Wistuba, M.D.
Edward Kim, M.D.
MD Anderson Cancer Center
University of Texas
Houston, TX
The Identification of Biomarkers for Predicting Response to Treatment in Advanced Non-Small Cell Lung Cancer

2009 Grants 

2009 V Foundation V Scholars

Rajat Rohatgi, M.D., Ph.D.
Stanford Cancer Center
Stanford, CA 
Martin D. Abeloff, M.D. V Scholar Award
Dissecting the role of the tumor suppressor Sufu in Hedgehog-driven cancers

Mohammad Azam, Ph.D.
Cincinnati’s Children’s Hospital Medical Center
University of Cincinnati
Cincinnati, OH 
In memory of Anthony Negrin
Molecular and therapeutic analysis of myeloid leukemia using human induced-pluripotent stem cells

Rmaeen Beroukhim, M.D., Ph.D.
Dana-Farber Cancer Institute
Boston, MA
Developing a robust method for genotyping copy-number alterations in clinical samples of low tumor purity

Fernando D. Camargo, Ph.D.
Children’s Hospital Boston
Boston, MA
An Emerging Tumor Suppressor Pathway in Human Cancer

Iona Cheng, Ph.D., MPH
University of Hawaii
Cancer Research Center of Hawaii
Honolulu, Hawaii
Identifying IFF1 Genetic Susceptibility Variants for Prostate Cancer in African Americans

Andrei Goga, M.D., Ph.D.
University of California at San Francisco
Helen Diller Family Comprehensive Cancer Center
San Francisco, CA
Synthetic-Lethal Strategies to Target Embryonic Stem Cells (ESCs) and Tumor Stem Cells (TSCs)

Ya-Huei Kuo, Ph.D.
City of Hope National Medical Center & Beckman Research Institute
Duarte, CA
Mechanism of inv(16)-induced acute myeloid leukemia stem cell generation and maintenance:  implications for targeted therapy

Roger Lo, M.D., Ph.D.
University of California, Los Angeles
Jonsson Comprehensive Cancer Center
Los Angeles, CA
Albert Wyrick V Scholar
Genomic Determinants of Melanoma Sensitivity to V600EB-Raf Targeting

Minkui Luo, Ph.D.
Memorial Sloan-Kettering Cancer Center
New York, NY
Protein Arginine Methylation Profiling in Cancer

Leta K. Nutt, Ph.D.
St. Jude Children’s Research Hospital
Memphis, TN
Metabolic regulation of caspase-2 activation

Tobias Peikert, M.D.
Mayo Clinic
Rochester, MN
Measles Virus Mediated Immune Modulation and Anti-tumor Immunity within the Tumor 
Microenvironment in Patients with Human Non-Small Cell Lung Cancer

Sandro Santagata, M.D., Ph.D.
Brigham and Women’s Hospital 
Harvard Medical School
Boston, MA
Heat Shock Guided Drug Discovery – Identifying Novel Targets for the Treatment of Cancer

Emmanuel Skordalakes, Ph.D.
The Wistar Institute
Philadelphia, PA
Molecular Basis for Telomerase Replication 

Shobha Vasudevan, Ph.D.
Massachusetts General Hospital Cancer Center 
Boston, MA
MicroRNP Regulation of VEGF in Breast Cancer

Thomas Westbrook, Ph.D.
Baylor College of Medicine
Dan L. Duncan Cancer Center
Houston, TX
A New Approach to Therapeutic Discovery in Breast Cancer

Catherine Yan, Ph.D.
Thomas Westbrook, Ph.D.
Beth Israel Deaconess Medical Center
Harvard Medical School
Boston, MA 
Identification of genetic and epigenomic regulators of malignant transformation in human disease

Qin Yan, Ph.D.
Yale Cancer Center
Yale University
New Haven, CT
Roles of Histone Demethylase Retinoblastoma Binding Protein 2 in Cancer

2009 Designated Grants

Steven M. Curley, M.D.
The University of Texas
MD Anderson Cancer Center
Houston, TX
Funded by 2009 Celebrity Golf Classic
In Honor of Arnold Palmer

Jim Ford, M.D.
Stanford University School of Medicine
Palo Alto, CA
Funded by The Gastric Cancer Foundation

Paola Gehrig, M.D.
UNC Lineberger Cancer Center
Chapel Hill, NC
Funded by Dessert First Raleigh
In Memory of Kay Yow

Gregory Hale, M.D.
All Children’s Hospital
St. Petersburg, FL
Funded by 2009 Dick Vitale Gala

Anthony Heaney, M.D., Ph.D.
UCLA Jonsson Comprehensive Cancer Center
Los Angeles, CA
Funded by UNICO
In memory of Frank Milo 

Norman Lacayo, M.D. & Gary Dahl, M.D.
Stanford University Comprehensive Cancer Center
Palo Alto, CA
Funded by George and Susan Levin

Richard Reiling, M.D.
Presbyterian Hospital
Charlotte, NC
Funded by Dessert First Charlotte

Steven Sherman, M.D.
M.D. Anderson Cancer Center
Houston, TX
Funded by 2008 Vintner Grant 
In honor of Stephanie Putnam

Jill M. Siegfried, Ph.D.
University of Pittsburgh Cancer Institute
Pittsburgh, PA
Supplement to the Lung Cancer Specialized Program of Research Excellence
Funded by Vintner Grant 
In Honor of Emily Miner

Michael Welch, Ph.D & John Stephen Taylor, Ph. D.
Siteman Cancer Center
Washingtion University School of Medicine
St. Louis, MO
Funded by the Kay Yow/WBCA Fund 

Zhong Zheng, M.D., Ph.D.
H. Lee Moffitt Cancer Center and Research Institute
Tampa, FL
Funded by 2009 Dick Vitale Gala Putnam

2009 Translational Grants

Stephen Gottschalk, M.D.
Nabil Ahmed, M.D., M.P.H
Lisa Lynn Wang, M.D.
Baylor College of Medicine
Houston, TX
Adoptive Immunotherapy for Osteosarcoma

Douglas V. Faller, Ph.D., M.D.
Susan Perrine, M.D.
Boston University School of Medicine
Boston, MA 
Virus-targeted therapeutic for Epstein-Barr Virus-Associated Lmphomas

Saiaowen David Hsu, M.D., Ph.D.
Anil Potti, M.D.
Duke University Medical Center
Durham, NC
Development of a paraffin-based assay to predict patients with early stage colorectal cancer at high risk for recurrence
In Memory of Alan Roos Sr and Charlie Halloran Sr

Christine A. Iacobuzio-Donahue, M.D,. Ph.D.
Victor Velculescu, M.D., Ph.D.
Johns Hopkins Medical Institutions
Baltimore, MD
High Throughput Sequencing of Pancreatic Intraepithelial Neoplasia

Alice Shaw, M.D., Ph.D.
Jeffrey Engelman, M.D., Ph.D.
Massachusetts General Hospital Cancer Center
Boston, MA
Novel Therapeutic and Diagnostic Approaches to Lung Cancers Harboring ALK Fusion Oncogenes

Anna R. Giuliano, Ph.D.
Soner Altiok, M.D., Ph.D.
Gerold Bepler, M.D., Ph.D.
Douglas Cress, Ph.D.
Hui-Yi Lin, Ph.D.
Matthew B. Schabath, Ph.D.
H. Lee Moffitt Cancer Center
Tampa, FL
Viruses in Pulmonary (VIP) Carcinoma

Feyruz Rassool, Ph.D.
Greenebaum Cancer Center
Univeristy of Maryland
Baltimore, MD
Targeting Abnormal DNA Repair Pathways in Leukemia Carcinoma

William Pao, M.D., Ph.D.
David Weaver, Ph.D.
Alex Waterson, Ph.D.
Vanderbilt-Ingram Cancer Center
Nashville, TN
Identification of Novel Small Molecule Inhibitors Selective Against A Major Drug Resistance Mutation in Lung Cancer 

2008 Grants

2008 V Scholar Grants

Jennifer R. Cochran, Ph.D.
Stanford University Comprehensive Cancer Center
Palo Alto, CA
Martin D. Abeloff, M.D. V Scholar Award
Engineering a new class of tumor-targeting peptides for cancer biology, imaging and therapy

Jessica K. Bell, Ph.D.
Virginia Commonwealth University
Massey Cancer Center
Richmond, VA
The role of double stranded RNA in stimulating cancer cell death

Daniela M. Dinulescu, Ph.D.
Brigham and Women’s Hospital
Harvard Medical School
Boston, MA
Targeting Cancer Stem Cells in Ovarian Cancer: Implications for Chemoresistance to Therapy

Pieter C. Dorrestein, 
University of California, San Diego
San Diego, CA
Anticancer drugs from the ocean

Jeffrey Engelman, M.D., Ph.D.
Massachusetts General Hospital
Boston, MA
Acquired Resistance to EGFR Inhibitors: The Next Generation

Wendy Garrett, M.D., Ph.D.
Dana-Farber Cancer Institute
Boston, MA
A new model of spontaneous ulcerative colitis-associated colorectal 

Josh Lauring, M.D., Ph.D.
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, MD
Receptor-mediated endocytosis of estrogens as a potential therapeutic target for breast cancer
Funded in Honor of Kay Yow

Stephen B. Long, Ph.D.
Memorial Sloan-Kettering Cancer Center
New York, NY
Atomic structures and mechanisms of the cancer targets Rce1 and ICMT
Funded by the NBA and NBA Referees Association in Honor of Ron Olesia

Jin Biao Ma, Ph.D.
UAB Comprehensive Cancer Center
University of Alabama at Birmingham
Birmingham, AL
Structures and mechanisms of RNA-binding proteins in the post-transcriptional regulation Of microRNAs associated with tumorigenesis 

Sendurai Mani, Ph.D.
M.D. Anderson Cancer Center
Houston, TX
Role of Epithelial-Mesenchymal Transition in the Generation of Cancer Stem Cellls and Metastasis
Funded by Delta Chi

Matthew D. Petroski, Ph.D.
Burnham Institute for Medical Research
La Jolla, CA
Dissecting the function and regulation of the SKP2 oncogenic protein for cancer therapeutic development

J. Michael Thompson, Ph.D.
Vanderbilt University Medical Center
Nashville, TN
Elucidating the mechanisms of regulated microRNA processing in Cancer

Lloyd C. Trotman, Ph.D.
Cold Spring Harbor Laboratory
Cold Spring Harbor, NY
Identification of Critical Gene-Alterations for the Progression of PTEN-Mutant Prostate Cancer

Wenyi Wei, Ph.D.
Beth Israel Deaconess Medical Center
Boston, MA
Characterize the role of the Akt oncoprotein in governing the substrate specifically of the APC/Cdh1 E3 ubiquitin complex

Angelique Whitehurst, Ph.D.
UNC Lineberger Cancer Center
University of North Carolina
Chapel Hill, NC
Harnessing Functional Genomics to Reveal Cancer Specific Determinants of Mitosis; 2007 JVCGC Volunteer Grant in Honor of Mike Howard 
2008 JVCGC Volunteer Grant in Honor of Mike Howard

2008 Designated Grants

David Azorsa, Ph.D.
Translational Genomics Research Institute
Scottsdale, AZ
Funded in Honor of Reed Kavner

Salvatore Bertolone, M.D.
Kosair Children’s Hospital
Louisville, KY 
Funded by Louisville Friends of V 

John Cavanagh, Ph.D.
Jimmy V –NC State University Cancer Therapeutics Training Program
North Carolina State University
Raleigh, NC 

Richard A. Drachman, M.D.
The Cancer Institute of New Jersey
Robert Wood Johnson Medical School
New Brunswick, NJ
Funded by UNICO in Memory of Leno Sodini  

Georgia Cancer Coalition 
Atlanta, Ga 
In Memory of Garry Betty

Katherine K. Matthay,M.D.
University of California at San Francisco, School of Medicine
San Francisco, CA 
Funded by The Wine Celebration

Michael Nieder, M.D.
All Children’s Hospital
St. Petersburg, FL
Funded by 2008 Dick Vitale Gala

W. Jack Pledger, Ph.D.
H. Lee Moffitt Cancer Center & Research Institute
Tampa, FL
Funded by 2008 Dick Vitale Gala

University of North Carolina Comprehensive Cancer Center
LIVESTRONG Survivorship Center of Excellence
Lance Armstrong Foundation
Chapel Hill, NC

Jeffrey Wolf, M.D. & Tom Martin, M.D.
University of California at San Francisco
Helen Diller Family Comprehensive Cancer Center
San Francisco, CA
In Honor of Tim and Donna Egan 

Jim Valvano Fellowship in Pediatric Cancer
Duke Children’s Hospital and Health Center
Durham, NC
Funded by Jimmy V Jr. and Jimmy V Celebrity Golf Classics 

2008 Translational Grants

Hal Broxmeyer, Ph.D.
Sherif S. Farag, M.D., Ph.D.
David Jones, Ph.D.
Indiana University Cancer Research Institute
Indianapolis, IN
Enhancing Cord Blood Stem Cell Engraftment by CD26 Inhibition in Patients with Hematological Cancers

Raju Chaganti, Ph.D.
Robert Motzer, M.D.
Memorial Sloan-Kettering Cancer Center
New York, NY
Molecular Mechanism of Sunitinib Response in RCC Patients: Novel Approaches to Therapy and Identification of Therapeutic Targets

Tanya B. Dorff, M.D.
Amy S. Lee, Ph.D.
Valter D. Longo, Ph.D.
David I. Quinn, MBBS, Ph.D., FRACP
USC/Norris Comprehensive Cancer Center
Los Angeles, CA
Pre-clinical and Clinical Studies of Fasting-induced Differential Stress Resistance to Enhance Cancer Treatment

Judy E. Garber, M.D., MPH
Daniel P. Silver, M.D., Ph.D.
Dana-Farber Cancer Institute
Boston, MA
Development of Predictive Markers of Treatment Response in Basal-like Breast Cancer

Howard Kipen, M.D., MPH
Helmut Zarbl, Ph.D.
Robert Wood Johnson Medical School
University of Medicine and Dentistry of New Jersey
New Brunswick, NJ
Chemoprevention of Breast and Prostate Cancers in Shift Workers by Dietary Methylselenocysteine: Effects on Circadian Rhythm and Estrogen Receptor Cycling

John P. Leonard, M.D.
Ari Melnick, M.D.
Weill Cornell Cancer Center
New York, NY
Epigenetic Therapy for Diffuse Large B Cell Lymphoma

Scott Powers, Ph.D.
Gary K. Schwartz, M.D.
Raffaella Sordella, Ph.D.
Cold Spring Harbor Laboratory
Memorial Sloan-Kettering
Cold Springs Harbor, NY
Multiplex RNAi Screening for Rational Combination Therapies in Melanoma

2007 Grants

2007 V Scholar Grants

Ian J. Davis, M.D., Ph.D.
UNC Lineberger Comprehensive Cancer Center
University of North Carolina
Chapel Hill, NC
Martin D. Abeloff, M.D. V Scholar Award
Targeting dysregulated transcription factors in pediatric malignancies.

James Brugarolas, M.D., Ph.D.
Simmons Comprehensive Cancer Center 
University of Texas Southwestern Medical Center
Dallas, TX
Evaluation of the mTOR pathway in renal-cell carcinoma and in model systems. 2007 JVCGC Volunteer Grant in Honor of Dave and Wanda Farley

Jack D. Bui, M.D., Ph.D.
Rebecca and John Moores Cancer Center
University of San Diego
La Jolla, CA
Enhancing tumor recognition by inducing NKG2D ligands

Dean Ho, Ph.D.
Robert H. Lurie Comprehensive Cancer Center
Northwestern University
Chicago, IL
Active Nanodiamond Hydrogels for Directed Chemotherapeutic Delivery

Susan M. Janicki, Ph.D.
The Wistar Institute
Philadelphia, PA
Live Cell Analysis of Histone Dynamics at Transcriptionally Active Chromatin

Carla Kim, Ph.D.
Children’s Hospital Boston
Boston, MA
Examination of cancer stem cells in lung cancer. In Memory of Christopher T. Carroll

Ju-Seog Lee, Ph.D.
University of Texas, M.D. Anderson Cancer Center
Houston, TX
Characterization of the interaction between astrocytes and cancer cells in breast cancer brain metastasis. 2007 Vintner Grant in Honor of Robin Lail

Gregory B. Lesinski, Ph.D.
James Cancer Hospital & Solove Research Institute
Columbus, OH
The Role of MicroRNA in the Progression of Malignant Melanoma. Funded by Buckeyes FORE Cancer Research

Takahiro Maeda, M.D., Ph.D.
City of Hope National Medical Center
Beckman Research Institute
Duarte, CA
The role of the proto-oncogene LRF in B cell malignancies: Implication for targeted therapy

Raul Mostoslavsky, M.D., Ph.D.
Massachusetts General Hospital Cancer Center
Boston, MA
The Role of SIRT6 in DNA repair and metabolic homeostatis

Vivian G. Oehler, M.D.
Fred Hutchinson Cancer Research Center
Seattle, WA
Prognostic factors in chronic myeloid leukemia progression and therapy resistance

Kathrin Plath, Ph.D.
UCLA School of Medicine
Los Angeles, CA
X chromosome reactivation and cancer in mouse models

Pamela M. Pollock, Ph.D.
Translational Genomics Research Institute (Tgen)
Phoenix, AZ
Activated FGFR2 as a novel therapeutic target in endometrial cancer

Edward M. Schaeffer, M.D., Ph.D.
Johns Hopkins Medical Institution
Baltimore, MD
Hedgehog Pathway activity in primary prostate cancer lesions predicts subsequent clinical failure and aggressive disease

Jean J. Zhao, Ph.D.
Dana-Farber Cancer Institute
Boston, MA
Dissecting the roles of the class 1A phosphatidylinositol 3-kinases in breast tissue development and tumor formation using genetic inactivation of selected isoform(s)

2007 Designated Grants

Emory Winship Cancer Institute and Georgia Institute of Technology
Atlanta, GA
Acoustic Microarray Sensor for Head and Neck Cancer xxx

Funded by Atlanta Friends of V

First Health Moore Regional Cancer Center
Pinehurst, NC
Prostate Cancer Survivorship Program
Funded by Jimmy V Celebrity Golf Classic

Jonsson Comprehensive Cancer Center
University of California, Los Angeles
V Foundation-Gil Nickel Endowed Fellowship in Melanoma Research
Funded by Gil Nickel Memorial

Joel Levine, M.D.
Carole and Ray Neag Comprehensive Cancer Center
Farmington, CT
Funded by UNICO International in memory of Anthony Gonnella 

James J. Mule, Ph.D.
H. Lee Moffitt Cancer Center
Tampa, FL
Funded by 2007 Dick Vitale Gala 

xxx Prostate Cancer Center of Excellence

Rex Hospital
Raleigh, NC
Funded by Jimmy V Celebrity Golf Classic

Ravi Salgia, M.D., Ph.D.
University of Chicago Cancer Research Center
Chicago, IL
Funded by Guy Geleerd Memorial

St. Helena Hospital Cancer Center
St. Helena, CA
Funded by the 2007 Wine Celebration

Alejandro Sweet-Cordero, M.D.
Stanford University School of Medicine
Stanford, CA
Funded by the Kavner Family in honor of Reed Kavner 

2007 Translational Grants

Kenneth D. Aldape, M.D.
The University of Texas MD Anderson Cancer Center
Houston, TX
Multigene Predictor to Individualize Patient Care of Glioblastoma 

Emily K. Bergsland, M.D.
Douglas Hanahan, Ph.D.
University of California San Francisco
San Francisco, CA
Rational Drug Utilization: Concurrent EGFR and mTOR blockade in patients with pancreatic Neuroendocrine tumors 

Ravi Bhatia, M.D.
Wen Yong Chen, Ph.D.
City of Hope
Duarte, CA
Epigenetic mechanisms of chemoresistance of chronic myelogenous leukemia 

Marcia Canto, M.D., MHS
Michael Groggins, M.D.
Sidney Kimmel Comprehensive Cancer Center 
Johns Hopkins
Baltimore, MD
Expanding the target population for pancreatic cancer screening 

Paul Dent, Ph.D.
Steven Grant, M.D.
Mohamed Rahmani, Ph.D.
John Roberts, M.D.
Virginia Commonwealth University-Massey Cancer Center
Richmond, VA
Reestablishing the leukemia cell death program with sorafenib and Bcl-2 antagonists 

Michael Kahn, Ph.D.
Yong-Mi Kim, M.D., Ph.D.
Markus Müschen, M.D.
Allen S. Yang, M.D., Ph.D.
USC/Norris Comprehensive Cancer Center
Los Angeles, CA
Targeting CBP/ß -catenin signaling in acute lymphoblastic leukemia stem cells 

2006 Grants

2006 V Scholar Grants

Eric J. Brown, Ph.D.
Abramson Cancer Center
University of Pennsylvania
Philadelphia, PA
A Genetic Screen to Identify Genes Essential for the Viability of BRCA1 and BRCA2 Mutant Cells 
Funded by Jimmy V Celebrity Golf Classic in Honor of Kathy O’Brien 

Charles G. Drake, M.D., Ph.D.
Sidney Kimmel Comprehensive Cancer Center
at Johns Hopkins University 
Baltimore, MD
The Role of PD-1 in The Acute T Cell Response to Cancer 

Seth J. Field, M.D., Ph.D.
Rebecca and John Moores UCSD Cancer Center
University of California, San Diego
San Diego, CA
Function of Novel Targets of PtdIns (3,4,5) P3 in Oncogenic Tranformation 

Michael T. Hemann, Ph.D.
MIT Center for Cancer Research
Massachusetts Institute of Technology
Cambridge, MA
Investigating chemotherapeutic action using in vivo RNAi

Konrad Hochedlinger, Ph.D.
Massachusetts General Hospital Cancer Center
Boston, MA
Role of Quiescence in Stem Cells and Cancer 
2006 Vintner Grant in Honor of Chuck and Anne McMinn 

Qihong Huang, M.D., Ph.D.
The Wistar Institute
Philadelphia, PA
Identification and Characterization of Stage Specific Metastasis Promoting MicroRNAs Using a Functional Genomics Approach 

Eric C. Lai, Ph.D.
Memorial Sloan-Kettering Cancer Center
New York, NY
Genetic Identification of Cancer-Relevant MicroRNA Activities and Novel MicroRNA Pathway Components 

Hanna Mikkola, M.D., Ph.D.
Jonsson Comprehensive Cancer Center
University of California, Los Angeles
Los Angeles, CA
EtO-2 and Epigenetic Regulation of Hematopoietic Stem Cell Development and Leukemia 

Piers Nash, Ph.D.
University of Chicago Cancer Research
Chicago, IL
Modulation of Growth Factor Receptor Signaling and Trafficking via Reversible Ubiquitination 

Erik A. Ranheim, M.D., Ph.D.
UW Paul P. Carbone Comprehensive Cancer Center
University of Wisconsin
Madison, WI
The Role of the Beta-Catenin Signaling Pathway in Normal and Malignant Stem Cell Behavior 

Stefan Riedl, Ph.D.
The Burnham Institute 
La Jolla, CA
Exploring the Structural Mechanisms of Cancer Signaling Complexes for Drug Development 

Laura Rush, DVM, Ph.D.
Comprehensive Cancer Center
The Ohio State University 
Columbus, OH
A Transgenic Mouse Model for Elucidating the Role of DNMT3b in Hematopoietic Malignancies 

Reuben J. Shaw, Ph.D.
Salk Institute Cancer Center
Salk Institute
La Jolla, CA
Role of LKB1/AMPK Signaling in Tumor Growth and Metabolism 

Muneesh Tewari, M.D., Ph.D.
Fred Hutchinson/University of Washington Cancer Consortium
Fred Hutchinson Cancer Research Center
Seattle, WA
Silencing of microRNA Genes in Colon Cancer by Genomic Methylation 

Zhenge John Wang, Ph.D.
Case Comprehensive Cancer Center
Case Western Reserve University
Cleveland, OH
Dissecting tumor suppressor signaling of receptor tyrosine phosphatase T in colorectal cancer

2006 Designated Grants

Georgia Tech Emory Program for Innovative Cancer Technologies
Winship Cancer Institute
Atlanta, GA
Support of Emory-Georgia Tech Nanotechnology Center for Personalized and Predictive Oncology 
Funded by 2006 Atlanta Friends of V 

Peter Albertsen, M.D.
Carole and Ray Neag Comprehensive Cancer Center 
University of Connecticut Health Center
Farmington, CT
The Potential Role of Estrogen on the Inhibition of Both Osteoclastogenisi and Skelton Metastasis Formation in Men with Prostate Cancer: A Pilot Study 
Funded by the 2006 Spirit of Jimmy V Gala in Honor of Coach Jim Calhoun 

Salvatore Bertolone, M.D.
Children’s Hospital Foundation 
Kosair Children’s Hospital
Louisville, KY
Research Project in Pediatric Neuroblastoma 
Funded by the Louisville Friends of V 

Stephen Forman, M.D.
City of Hope National Medical Center
Beckman Research Institute
Duarte, CA
Tim Nesvig Research Fund for Lymphoma Research 
Funded by ESPN in Memory of Tim Nesvig 

Robert Greiner, M.D.
Duke Children’s Hospital and Health Center
Durham, NC
Jim Valvano Fellowship in Pediatric Cancer Research 
Funded by the Chuck and Anne McMinn Family and The Jimmy V Celebrity Junior Golf Tournament 

Sridharan Gururangan, M.D.
Hai Yan , M.D., Ph.D
The Preston Robert Tisch Brain Tumor Center
Duke University Medical Center
Durham, NC
In Honor of Payton Wright 

Alok Khorana, M.D.
James P. Wilmont Cancer Center at Strong
University of Rochester Medical Center
Rochester, NY
Identifying Biomarkers of Thromboembolism in Colorectal Cancer Patients Receiving Bevacizumab 
Funded by Marketing Research Consultants in Honor of Gil Hatch 

Joseph Nevins, M.D.
Duke Comprehensive Cancer Center
Duke University Medical Center
Durham, NC
Programs to Develop Genomic Strategies for Personalized Cancer Treatment 
Partners In Excellence collaborative grant with UNC Lineberger Comprehensive Cancer Center in Honor of Jamie Valvano Howard and Kelly Jo Dowd 

Charles Perou, M.D.
UNC Lineberger Comprehensive Cancer Center
University of North Carolina at Chapel Hill
Chapel Hill, NC
Programs to Develop Genomic Strategies for Personalized Cancer Treatment 
Partners In Excellence collaborative grant with Duke Comprehensive Cancer Center in Honor of Jamie Valvano Howard and Kelly Jo Dowd 

Aleksandra Petrovic, M.D.
All Children’s Hospital Foundation
St. Petersburg, FL
T-Cell Homing in Intestinal Graft Versus Host Disease 
Funded by 2006 Dick Vitale’s Evening with the Stars in Honor of Timmy Berg 

Shari Pilon-Thomas, Ph.D.
H. Lee Moffitt Cancer Center and Research Institute
University of South Florida
Tampa, FL
Radiation Therapy Followed by T Cell Transfer and Dendritic Cell Immunotherapy for the Treatment of Established Melanoma Funded by 2006 Dick Vitale’s Evening with the Stars

George Y.C. Wong, Ph.D.
Strang Cancer Prevention Center
New York, NY
Chinese Herbal Medicine Research Program for Breast Cancer 
Funded by the 2006 Spirit of Jimmy V Gala in Honor of Coach Jim Boeheim

2006 Translational Grants

Vadim Backman, Ph.D.
Robert H. Lurie Comprehensive Cancer Center
Northwestern University
Chicago, IL
Noninvasive Diagnosis of Early Pancreatic Cancer: a Biophotonics Approach 

Alan P. Fields, Ph.D.
Mayo Clinic Cancer Center
Jacksonville, FL
Inhibition of Oncogenic PKCι in the treatment of Squamous Cell Carcinoma of the Lung
Vintner Grant in Honor of Todd Zapolsky and Leslie Rudd

Anil Potti, M.D.
Duke Comprehensive Cancer Center
Duke University Medical Center
Durham, NC
Signatures of Oncogenic Pathway Deregulation Provide a Novel Approach to Targeted Therapeutics in Non-small Cell Lung Carcinoma 
2006 Jimmy V Celebrity Golf Classic Volunteer Grant in Honor of David Ingraham and Jeff Slack 

Ann Richmond, Ph.D.
Jeff Sosman, M.D.
Vanderbilt-Ingram Cancer Center
Vanderbilt University
Nashville, TN
Over the past few years, the understanding of the specific gains and losses of critical cell functions in melanoma have generated excitement for targeted therapy in this disease. We now know of a number of critical pathways within the melanoma cell regulated by specific enzyme proteins, called kinases, that no longer function normally. We will study the effect of blocking these pathways with new inhibitors in hope of improving the clinical outcome of melanoma patients. 

Kevin Shannon, M.D.
UCSF Comprehensive Cancer Center & Cancer Research Institute
University of California San Francisco
San Francisco, CA
Targeting Deregulated Signaling Networks in Leukemia Stem Cells 
In Honor of Beth Jarvis 

Robert H. Silverman, Ph.D.
Cleveland Clinic Foundation – Lerner Research Institute
Cleveland, OH
Monitoring XMRV Infections in Prostate Cancer 

2005 Grants 

2005 V Scholar Grants

Robert Baiocchi, M.D., Ph.D.
Comprehensive Cancer Center
The Ohio State University
Columbus, OH
Exploring mechanisms of resistance to histone deacetylase inhibitor-induced apoptosis in Epstein-Barr virus associated malignancies 

Pilar Blancafort, Ph.D.
UNC Lineberger Comprehensive Cancer Center
University of North Carolina at Chapel Hill
Chapel Hill, NC
Regulation of metastatic progression of breast tumors by zinc finger transcription factors selected from combinatorial libraries 2005 JVCGC Volunteer Grant in honor of Julie Stewart 

Wei Chen, Ph.D.
Duke Comprehensive Cancer Center
Duke University Medical Center
Durham, NC
Regulation of Hedgehog/Smoothened Signaling in Pancreatic Cancer 

Nadia Dahmane, Ph.D.
The Wistar Institute
Philadelphia, PA
Mechanisms regulating cerebellar development and medulloblastoma 

Randall S. Davis, M.D.
UAB Comprehensive Cancer Center
University of Alabama at Birmingham
Birmingham, AL
Role of Fc Receptor Homologs in B Cell Malignancy 

Patricia Ernst, Ph.D.
Norris Cotton Cancer Center
Dartmouth-Hitchcock Medical Center
Hanover, NH
Epigenetic Mechanisms of Leukemogenesis: Defining MLL-Dependent Pathways Governing Cell Growth and Differentiation 

Elsa R. Flores, Ph.D.
MD Anderson Cancer Center
University of Texas
Houston, TX
Investigating the roles of p63 and p73 in anti-tumorigenic pathways 

Ananda W. Goldrath, Ph.D.
Rebecca and John Moores UCSD Cancer Center
University of California, San Diego
San Diego, CA
Control of memory T cell generation and lymphoma formation by E protein transcription factors Funded by the NFL Referees Association in memory of Jack Gatto 

Johanna Joyce, Ph.D.
Memorial Sloan-Kettering Cancer Center
New York, NY
Dissecting the role of cysteine cathepsins in cancer Funded in memory of Linda Rekant 

Anthony Letai, M.D., Ph.D.
Dana-Farber/Harvard Cancer
Dana-Farber Cancer Institute
Boston, MA
Targeting viral-mediated escape from apoptosis in cancer 

Kevin D. Mills, Ph.D.
The Jackson Laboratory Cancer Center
Bar Harbor, ME
Homologous Recombination in Genome Stability and Tumor Suppression 

Gary W. Reuther, Ph.D.
H. Lee Moffitt Cancer Center and Research Institute
University of South Florida
Tampa, FL
Characterization of a Novel Mutation in the Interleukin-27 Receptor in Acute Myeloid Leukemia 

Davide Ruggero, Ph.D.
Fox Chase Cancer Center
Philadelphia, PA
Role of elF4E in Control of Programmed Cell Death and Tumorigenesis 

Toshiyasu Taniguchi, M.D., Ph.D.
Fred Hutchinson/University of Washington Cancer Consortium
Fred Hutchinson Cancer Research Center
Seattle, WA
Mechanism of BRCA2/FANCD1 protein inactivation/reactivation in ovarian cancer cells during cisplatin treatment 

Osamu Tetsu, M.D., Ph.D.
UCSF Comprehensive Cancer Center & Cancer Research Institute
University of California, San Francisco
San Francisco, CA
Identification of the E3 ligase for cyclin D1 ubiquitination and degradation Funded by The Wine Celebration in honor of Michael Holmes 

Lisa L. Wang, M.D.
Texas Children’s Cancer Center
Houston, TX
Mechanism of Aneuploidy in a Genetic Model of Osteosarcoma 

Rui Zhao, Ph.D.
University of Colorado Cancer Center
University of Colorado at Denver & Health Sciences
Denver, CO
Structural analyses of Six1 transcriptional complexes for anti-cancer drug design 

Lee Zou, Ph.D.
Massachusetts General Hospital Cancer Center
Boston, MA
Checkpoint Signaling and the Stability of Fragile Sites in Human Cells 

2005 Designated Grants

Georgia Tech Emory Program for Innovative Cancer Technologies
Atlanta, GA
Funded by Atlanta Friends of V 

Salvatore Bertolone, M.D.
Kosair Children’s Hospital
Louisville, KY
Funded by Louisville Friends of V 

Jessica Fu, M.D.
UNC Lineberger Comprehensive Cancer Center
University of North Carolina at Chapel Hill
Chapel Hill, NC
Funded by 2005 Junior Jimmy V Celebrity Golf Classic 

Paola Gehrig, M.D.
UNC Lineberger Comprehensive Cancer Center
University of North Carolina at Chapel Hill
Chapel Hill, NC
Funded by 2004 Jimmy V Women’s Basketball Classic 

Gary Onik, M.D.
Florida Hospital Celebration Health
Celebration, FL
Funded by Anglers Against Cancer 

Charles Powell, M.D.
Herbert Irving Comprehensive Cancer Center
New York, NY
Funded by UNICO International in memory of Richard Juliano 

Gwen Quinn, Ph.D.
H. Lee Moffitt Cancer Center and Research Institute
University of South Florida
Tampa, FL
Funded by Tampa Friends of V 

Michel Sadelain, M.D., Ph.D.
Memorial Sloan-Kettering Cancer Center
New York, NY
Funded by the 2005 Spirit if Jimmy V New York Gala In honor of Rudolph W. Giuliani 

2005 Translational Grants

D. Gary Gilliland, M.D., Ph.D.
James D. Griffin, M.D.
Martin Sattler, Ph.D.
Richard Stone, M.D.
Martha Wadleigh, M.D.
Dana-Farber/Harvard Cancer Center
Dana-Farber Cancer Institute
(Boston, MA)
Developing Novel Therapies for Myeloproliferative Diseases
Funded by the AACR Foundation 

Susan Groshen, Ph.D.
Robert D. Ladner, Ph.D.
Heinz-Josef Lenz, M.D.
USC/Norris Comprehensive Cancer Center
University of Southern California
Los Angeles, CA
Histone Deacetylase Inhibitors as a Novel Approach to Combination Chemotherapy in Colon Cancer 

Donn C. Young, Ph.D.
Comprehensive Cancer Center
The Ohio State University
Columbus, OH
Evaluating the Genetics and Pharmacodynamics of EGFR Blockade in African Americans with Lung Cancer 2005 JVCGC Benefactor Award in honor of Charles Barkley