Research

Articles

Nora Heisterkamp, Ph.D.

2012 V Foundation Translational Grant recipient, Dr. Nora Heisterkamp, and her colleagues at The Saban Research Institute of Children’s Hospital Los Angeles recently published significant research findings regarding acute lymphoblastic leukemia (ALL) in Molecular Cancer Therapeutics. ALL, which is more common in children, is characterized by an overproduction of immature white blood cells (lymphoblasts). The lymphoblasts continuously multiply in the bone marrow, causing the damage or destruction of normal blood cells. Dr. Heisterkamp and her team have discovered that by using an antibody to target a particular receptor found on chemotherapy-resistant cells, they can selectively kill cancer cells both in […]

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Zachary T. Schafer, Ph.D.

A team of researchers led by 2011 V Scholar grant winner Zachary T. Schafer, Coleman Assistant Professor of Cancer at the University of Notre Dame, has uncovered important new data about carcinoma-associated fibroblasts (CAFs) and their role in tumor biology. CAFs play a major role in tumor progression, but exactly how is not understood. In their paper, Schafer and his team describe a critical role of CAFs in blocking anoikis, a cell death process that inhibits the spread of tumor cells to distant sites, through the secretion of insulin-like growth factor-binding proteins (IGFBPs). They revealed the exact molecular mechanism utilized by IGFBPs […]

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Timothy Burns, M.D., Ph.D.

Lung cancer is the leading cause of cancer death – more people die of lung cancer than of colon, breast, and prostate cancers combined. Finding the right therapy for lung cancer has proven difficult. Recent research has focused on sequencing different lung cancer mutations and allowing researchers to identify effective drug variations for some of those mutations. Timothy Burns is a 2013 V Scholar grant winner with a personal connection to lung cancer. Having lost both parents to the disease, he is focused on researching targeted therapies for the KRAS mutation of non-small cell lung cancer. The KRAS mutation accounts […]

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Glenn Bubley, M.D.

Glenn Bubley is the associate professor of medicine at Harvard Medical School, director of genitourinary oncology at Beth Israel Deaconess Medical Center, and a 2012 translational grant winner. He collaborated on the recent peer-reviewed article “Subjective Endpoints in Clinical Trials: the Case for Blinded Independent Review,” published in Open Access Journal of Clinical Trials. Dr. Bubley’s article distills ten years of experience with Endpoint Assessment Committee (EAC) work to provide a process map for maximizing the precision and accuracy of independent reviews of clinical trials.   According to WorldCare Clinical, primary efficacy and safety endpoints are often subjective assessments made by […]

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Rameen Beroukhim, M.D., Ph.D.

The Cancer Genome Atlas, a project launched by America’s National Institutes of Health, has assembled genetic data on thousands of tumors and made it available to anyone who wants to analyze it. Thanks to these DNA sequencing studies, researchers have unprecedented information on the molecular changes which propel cancer. Rameen Beroukhim, M.D., Ph.D., a 2009 V Scholar, is one of the researchers making sense of the data and putting it to use. He has examined almost 5,000 specimens from 11 traditionally defined types of cancer and found 140 regions of DNA that were sometimes either multiplied repeatedly or deleted altogether. […]

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Judy Garber, M.D., M.P.H.

Judy Garber, M.D., M.P.H. received a translational grant from The V Foundation in 2008 to support her breast cancer research. She is the director of the Center for Cancer Genetics and Prevention at the Dana-Farber Cancer Institute, and has recently been elected to the Institute of Medicine (IOM), a nongovernmental organization that advises the nation on issues related to biomedical science, medicine, and health. With breast cancer as their primary focus, Garber and her colleagues are leading studies of the long-term psychosocial and medical effects of genetic testing. Her work centers on identifying people with genetic factors that place them […]

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Dr. Lisa Diller, M.D.

Dr. Lisa Diller received a translational grant in 2012 from The V Foundation to further her research for pediatric cancer. She works at the Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, as Chief Medical Officer. To recognize September as Childhood Cancer Awareness Month, Dr. Diller is reminding parents to stay strong for the 12,000 children battling cancer in the United States. Since the 1970s, the five-year survival rate for pediatric cancer has increased from 58 percent to 83 percent. Here is a complete list of tips for parents with children battling cancer.

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Dr. Sandeep Dave, M.D., M.S.

In 2012, Dr. Sandeep Dave, an associate professor of Medicine at the Duke Cancer Institute, received a translational grant from The V Foundation for Cancer Research. After receiving an additional substantial grant, Dr. Dave and Dr. Patricia Lugar are looking to find a genetic relationship between Common Variable Immune Deficiency and lymphoma to come up with better diagnostics for treatment.  Because there is limited research done on CVID, many people are being misdiagnosed. Dr. Dave believes that doctors can provide an early diagnose and cure patients if they prove that a subset of CVID patients are at high risk of […]

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Anthony Oro, M.D., Ph.D.

It has only been one year since The V Foundation awarded Anthony Oro, M.D., Ph.D. a Translational Grant. His research focused on finding more effective treatments for skin cancer. In February 2013, Oro and a team of researchers at the Stanford University School of Medicine identified a new approach to treating skin cancer that will help patients who are resistant to some drugs and treatments. Oro’s research is similar to other researchers in that it was funded by The V Foundation. Initial Foundation funding continually leads to breakthroughs in cancer research. Funding to researchers like Oro remind us all that […]

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Christopher Vakoc, M.D., Ph.D.

Dr. Christopher Vakoc from Cold Spring Harbor Laboratory received a V Scholar grant from The V Foundation in 2012. Vakoc and his team have recently learned how to systematically disable individual genes in cancer cells by altering nucleic acids. This discovery will hopefully allow researchers to find specific vulnerabilities in these cells that may eventually lead to a cure for cancer. Read more about Vakoc and his team’s most recent discovery here. 

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