2008 Translational Grants

Hal Broxmeyer, Ph.D.
Sherif S. Farag, M.D., Ph.D.
David Jones, Ph.D.
Indiana University Cancer Research Institute
(Indianapolis, IN)
Enhancing Cord Blood Stem Cell Engraftment by CD26 Inhibition in Patients with Hematological Cancers

Raju Chaganti, Ph.D.
Robert Motzer, M.D.
Memorial Sloan-Kettering Cancer Center
(New York, NY)
Molecular Mechanism of Sunitinib Response in RCC Patients: Novel Approaches to Therapy and Identification of Therapeutic Targets

Tanya B. Dorff, M.D.
Amy S. Lee, Ph.D.
Valter D. Longo, Ph.D.
David I. Quinn, MBBS, Ph.D., FRACP
USC/Norris Comprehensive Cancer Center
(Los Angeles, CA)
Pre-clinical and Clinical Studies of Fasting-induced Differential Stress Resistance to Enhance Cancer Treatment

Judy E. Garber, M.D., MPH
Daniel P. Silver, M.D., Ph.D.
Dana-Farber Cancer Institute
(Boston, MA)
Development of Predictive Markers of Treatment Response in Basal-like Breast Cancer

Howard Kipen, M.D., MPH
Helmut Zarbl, Ph.D.
Robert Wood Johnson Medical School
University of Medicine and Dentistry of New Jersey
(New Brunswick, NJ)
Chemoprevention of Breast and Prostate Cancers in Shift Workers by Dietary Methylselenocysteine: Effects on Circadian Rhythm and Estrogen Receptor Cycling

John P. Leonard, M.D.
Ari Melnick, M.D.
Weill Cornell Medical College
(New York, NY)
Epigenetic Therapy for Diffuse Large B Cell Lymphoma

Scott Powers, Ph.D.
Gary K. Schwartz, M.D.
Raffaella Sordella, Ph.D.
Cold Spring Harbor Laboratory
Memorial Sloan-Kettering
(Cold Springs Harbor, NY)
Multiplex RNAi Screening for Rational Combination Therapies in Melanoma

2007 V Scholar Grants

Susan M. Janicki, Ph.D.
The Wistar Institute
(Philadelphia, PA)
Live Cell Analysis of Histone Dynamics at Transcriptionally Active Chromatin

Carla Kim, Ph.D.
Children’s Hospital Boston
(Boston, MA)
Examination of cancer stem cells in lung cancer. In Memory of Christopher T. Carroll

Ju-Seog Lee, Ph.D.
University of Texas, M.D. Anderson Cancer Center
(Houston, TX)
Characterization of the interaction between astrocytes and cancer cells in breast cancer brain metastasis. 2007 Vintner Grant in Honor of Robin Lail

Gregory B. Lesinski, Ph.D.
James Cancer Hospital & Solove Research Institute
(Columbus, OH)
The Role of MicroRNA in the Progression of Malignant Melanoma. Funded by Buckeyes FORE Cancer Research

Raul Mostoslavsky, M.D., Ph.D.
Massachusetts General Hospital Cancer Center
(Boston, MA)
The Role of SIRT6 in DNA repair and metabolic homeostatis

Vivian G. Oehler, M.D.
Fred Hutchinson Cancer Research Center
(Seattle, WA)
Prognostic factors in chronic myeloid leukemia progression and therapy resistance

Kathrin Plath, Ph.D.
UCLA School of Medicine
(Los Angeles, CA)
X chromosome reactivation and cancer in mouse models

Pamela M. Pollock, Ph.D.
Translational Genomics Research Institute (Tgen)
(Phoenix, AZ)
Activated FGFR2 as a novel therapeutic target in endometrial cancer

Edward M. Schaeffer, M.D., Ph.D.
Johns Hopkins Medical Institution
(Baltimore, MD)
Hedgehog Pathway activity in primary prostate cancer lesions predicts subsequent clinical failure and aggressive disease

Jean J. Zhao, Ph.D.
Dana-Farber Cancer Institute
(Boston, MA)
Dissecting the roles of the class 1A phosphatidylinositol 3-kinases in breast tissue development and tumor formation using genetic inactivation of selected isoform(s)

James Brugarolas, M.D., Ph.D.
Simmons Comprehensive Cancer Center
University of Texas Southwestern Medical Center
(Dallas, TX)
Evaluation of the mTOR pathway in renal-cell carcinoma and in model systems. 2007 JVCGC Volunteer Grant in Honor of Dave and Wanda Farley

Jack D. Bui, M.D., Ph.D.
Rebecca and John Moores Cancer Center
University of San Diego
(La Jolla, CA)
Enhancing tumor recognition by inducing NKG2D ligands

Ian J. Davis, M.D., Ph.D.
UNC Lineberger Comprehensive Cancer Center
University of North Carolina
(Chapel Hill, NC)
Targeting dysregulated transcription factors in pediatric malignancies.

Dean Ho, Ph.D.
Robert H. Lurie Comprehensive Cancer Center
Northwestern University
(Chicago, IL)
Active Nanodiamond Hydrogels for Directed Chemotherapeutic Delivery

Takahiro Maeda, M.D., Ph.D.
City of Hope National Medical Center
Beckman Research Institute
(Duarte, CA)
The role of the proto-oncogene LRF in B cell malignancies: Implication for targeted therapy

2007 Designated Grants

Joel Levine, M.D.
Carole and Ray Neag Comprehensive Cancer Center
(Farmington, CT)
Funded by UNICO International in memory of Anthony Gonnella

Ravi Salgia, M.D.
University of Chicago Cancer Research Center
(Chicago, IL)
Funded by Guy Geleerd Memorial

Alejandro Sweet-Cordero, M.D.
Stanford University School of Medicine
(Stanford, CA)
Funded by the Kavner Family in honor of Reed Kavner

2007 Translational Grants

Kenneth D. Aldape, M.D.
Howard Colman, M.D., Ph.D.
The University of Texas MD Anderson Cancer Center
(Houston, TX)
Multigene Predictor to Individualize Patient Care of Glioblastoma

Emily K. Bergsland, M.D.
Douglas Hanahan, Ph.D.
University of California San Francisco
(San Francisco, CA)
Rational Drug Utilization: Concurrent EGFR and mTOR blockade in patients with pancreatic Neuroendocrine tumors

Ravi Bhatia, M.D.
Wen Yong Chen, Ph.D.
City of Hope
(Duarte, CA)
Epigenetic mechanisms of chemoresistance of chronic myelogenous leukemia

Marcia Canto, M.D., MHS
Michael Groggins, M.D.
Sidney Kimmel Comprehensive Cancer Center
Johns Hopkins
(Baltimore, MD)
Expanding the target population for pancreatic cancer screening

Paul Dent, Ph.D.
Steven Grant, M.D.
Mohamed Rahmani, Ph.D.
John Roberts, M.D.
Virginia Commonwealth University-Massey Cancer Center
(Richmond, VA)
Reestablishing the leukemia cell death program with sorafenib and Bcl-2 antagonists

Michael Kahn, Ph.D.
Yong-Mi Kim, M.D., Ph.D.
Markus Müschen, M.D.
Allen S. Yang, M.D., Ph.D.
USC/Norris Comprehensive Cancer Center
(Los Angeles, CA)
Targeting CBP/ß -catenin signaling in acute lymphoblastic leukemia stem cells

2006 V Scholar Grants

Eric J. Brown, Ph.D.
Abramson Cancer Center
University of Pennsylvania
(Philadelphia, PA)
A Genetic Screen to Identify Genes Essential for the Viability of BRCA1 and BRCA2 Mutant Cells
Funded by Jimmy V Celebrity Golf Classic in Honor of Kathy O’Brien

Charles G. Drake, M.D., Ph.D.
Sidney Kimmel Comprehensive Cancer Center
at Johns Hopkins University
(Baltimore, MD)
The Role of PD-1 in The Acute T Cell Response to Cancer

Seth J. Field, M.D., Ph.D.
Rebecca and John Moores UCSD Cancer Center
University of California, San Diego
(San Diego, CA)
Function of Novel Targets of PtdIns (3,4,5) P3 in Oncogenic Tranformation

Michael T. Hemann, Ph.D.
MIT Center for Cancer Research
Massachusetts Institute of Technology
(Cambridge, MA)
Investigating chemotherapeutic action using in vivo RNAi

Konrad Hochedlinger, Ph.D.
Massachusetts General Hospital Cancer Center
(Boston, MA)
Role of Quiescence in Stem Cells and Cancer
2006 Vintner Grant in Honor of Chuck and Anne McMinn

Qihong Huang, M.D., Ph.D.
The Wistar Institute
(Philadelphia, PA)
Identification and Characterization of Stage Specific Metastasis Promoting MicroRNAs Using a Functional Genomics Approach

Eric C. Lai, Ph.D.
Memorial Sloan-Kettering Cancer Center
(New York, NY)
Genetic Identification of Cancer-Relevant MicroRNA Activities and Novel MicroRNA Pathway Components

Hanna Mikkola, M.D., Ph.D.
Jonsson Comprehensive Cancer Center
University of California, Los Angeles
(Los Angeles, CA)
EtO-2 and Epigenetic Regulation of Hematopoietic Stem Cell Development and Leukemia

Piers Nash, Ph.D.
University of Chicago Cancer Research
(Chicago, IL)
Modulation of Growth Factor Receptor Signaling and Trafficking via Reversible Ubiquitination

Erik A. Ranheim, M.D., Ph.D.
UW Paul P. Carbone Comprehensive Cancer Center
University of Wisconsin
(Madison, WI)
The Role of the Beta-Catenin Signaling Pathway in Normal and Malignant Stem Cell Behavior

Stefan Riedl, Ph.D.
The Burnham Institute
(La Jolla, CA)
Exploring the Structural Mechanisms of Cancer Signaling Complexes for Drug Development

Laura Rush, DVM, Ph.D.
Comprehensive Cancer Center
The Ohio State University
(Columbus, OH)
A Transgenic Mouse Model for Elucidating the Role of DNMT3b in Hematopoietic Malignancies

Reuben J. Shaw, Ph.D.
Salk Institute Cancer Center
Salk Institute
(La Jolla, CA)
Role of LKB1/AMPK Signaling in Tumor Growth and Metabolism

Muneesh Tewari, M.D., Ph.D.
Fred Hutchinson/University of Washington Cancer Consortium
Fred Hutchinson Cancer Research Center
(Seattle, WA)
Silencing of microRNA Genes in Colon Cancer by Genomic Methylation

Zhenge John Wang, Ph.D.
Case Comprehensive Cancer Center
Case Western Reserve University
(Cleveland, OH)
Dissecting tumor suppressor signaling of receptor tyrosine phosphatase T in colorectal cancer

2006 Designated Grants

Georgia Tech Emory Program for Innovative Cancer Technologies
Winship Cancer Institute
(Atlanta, GA)
Support of Emory-Georgia Tech Nanotechnology Center for Personalized and Predictive Oncology
Funded by 2006 Atlanta Friends of V

Peter Albertsen, M.D.
Carole and Ray Neag Comprehensive Cancer Center
University of Connecticut Health Center
(Farmington, CT)
The Potential Role of Estrogen on the Inhibition of Both Osteoclastogenisi and Skelton Metastasis Formation in Men with Prostate Cancer: A Pilot Study
Funded by the 2006 Spirit of Jimmy V Gala in Honor of Coach Jim Calhoun

2005 V Scholar Grants

Robert Baiocchi, M.D., Ph.D.
Comprehensive Cancer Center
The Ohio State University
(Columbus, OH)
Exploring mechanisms of resistance to histone deacetylase inhibitor-induced apoptosis in Epstein-Barr virus associated malignancies

Pilar Blancafort, Ph.D.
UNC Lineberger Comprehensive Cancer Center
University of North Carolina at Chapel Hill
(Chapel Hill, NC)
Regulation of metastatic progression of breast tumors by zinc finger transcription factors selected from combinatorial libraries 2005 JVCGC Volunteer Grant in honor of Julie Stewart

Wei Chen, Ph.D.
Duke Comprehensive Cancer Center
Duke University Medical Center
(Durham, NC)
Regulation of Hedgehog/Smoothened Signaling in Pancreatic Cancer

Nadia Dahmane, Ph.D.
The Wistar Institute
(Philadelphia, PA)
Mechanisms regulating cerebellar development and medulloblastoma

Randall S. Davis, M.D.
UAB Comprehensive Cancer Center
University of Alabama at Birmingham
(Birmingham, AL)
Role of Fc Receptor Homologs in B Cell Malignancy

Patricia Ernst, Ph.D.
Norris Cotton Cancer Center
Dartmouth-Hitchcock Medical Center
(Hanover, NH)
Epigenetic Mechanisms of Leukemogenesis: Defining MLL-Dependent Pathways Governing Cell Growth and Differentiation

Elsa R. Flores, Ph.D.
MD Anderson Cancer Center
University of Texas
(Houston, TX)
Investigating the roles of p63 and p73 in anti-tumorigenic pathways

Ananda W. Goldrath, Ph.D.
Rebecca and John Moores UCSD Cancer Center
University of California, San Diego
(San Diego, CA)
Control of memory T cell generation and lymphoma formation by E protein transcription factors Funded by the NFL Referees Association in memory of Jack Gatto

Johanna Joyce, Ph.D.
Memorial Sloan-Kettering Cancer Center
(New York, NY)
Dissecting the role of cysteine cathepsins in cancer Funded in memory of Linda Rekant

Anthony Letai, M.D., Ph.D.
Dana-Farber/Harvard Cancer
Dana-Farber Cancer Institute
(Boston, MA)
Targeting viral-mediated escape from apoptosis in cancer

Kevin D. Mills, Ph.D.
The Jackson Laboratory Cancer Center
(Bar Harbor, ME)
Homologous Recombination in Genome Stability and Tumor Suppression

Gary W. Reuther, Ph.D.
H. Lee Moffitt Cancer Center and Research Institute
University of South Florida
(Tampa, FL)
Characterization of a Novel Mutation in the Interleukin-27 Receptor in Acute Myeloid Leukemia

Davide Ruggero, Ph.D.
Fox Chase Cancer Center
(Philadelphia, PA)
Role of elF4E in Control of Programmed Cell Death and Tumorigenesis

Toshiyasu Taniguchi, M.D., Ph.D.
Fred Hutchinson/University of Washington Cancer Consortium
Fred Hutchinson Cancer Research Center
(Seattle, WA)
Mechanism of BRCA2/FANCD1 protein inactivation/reactivation in ovarian cancer cells during cisplatin treatment

Osamu Tetsu, M.D., Ph.D.
UCSF Comprehensive Cancer Center & Cancer Research Institute
University of California, San Francisco
(San Francisco, CA)
Identification of the E3 ligase for cyclin D1 ubiquitination and degradation Funded by The Wine Celebration in honor of Michael Holmes

Lisa L. Wang, M.D.
Texas Children's Cancer Center
(Houston, TX)
Mechanism of Aneuploidy in a Genetic Model of Osteosarcoma

Rui Zhao, Ph.D.
University of Colorado Cancer Center
University of Colorado at Denver & Health Sciences
(Denver, CO)
Structural analyses of Six1 transcriptional complexes for anti-cancer drug design

Lee Zou, Ph.D.
Massachusetts General Hospital Cancer Center
(Boston, MA)
Checkpoint Signaling and the Stability of Fragile Sites in Human Cells

2005 Designated Grants

Georgia Tech Emory Program for Innovative Cancer Technologies
(Atlanta, GA)
Funded by Atlanta Friends of V

Salvatore Bertolone, M.D.
Kosair Children’s Hospital
(Louisville, KY)
Funded by Louisville Friends of V

Jessica Fu, M.D.
UNC Lineberger Comprehensive Cancer Center
University of North Carolina at Chapel Hill
(Chapel Hill, NC)
Funded by 2005 Junior Jimmy V Celebrity Golf Classic

Paola Gehrig, M.D.
UNC Lineberger Comprehensive Cancer Center
University of North Carolina at Chapel Hill
(Chapel Hill, NC)
Funded by 2004 Jimmy V Women’s Basketball Classic

Gary Onik, M.D.
Florida Hospital Celebration Health
(Celebration, FL)
Funded by Anglers Against Cancer

Charles Powell, M.D.
Herbert Irving Comprehensive Cancer Center
(New York, NY)
Funded by UNICO International in memory of Richard Juliano

Gwen Quinn, Ph.D.
H. Lee Moffitt Cancer Center and Research Institute
University of South Florida
(Tampa, FL)
Funded by Tampa Friends of V

Michel Sadelain, M.D., Ph.D.
Memorial Sloan-Kettering Cancer Center
(New York, NY)
Funded by the 2005 Spirit if Jimmy V New York Gala In honor of Rudolph W. Giuliani

2005 Translational Grants

D. Gary Gilliland, M.D., Ph.D.
James D. Griffin, M.D.
Martin Sattler, Ph.D.
Richard Stone, M.D.
Martha Wadleigh, M.D.
Dana-Farber/Harvard Cancer Center
Dana-Farber Cancer Institute
(Boston, MA)
Developing Novel Therapies for Myeloproliferative Diseases
Funded by the AACR Foundation

Susan Groshen, Ph.D.
Robert D. Ladner, Ph.D.
Heinz-Josef Lenz, M.D.
USC/Norris Comprehensive Cancer Center
University of Southern California
(Los Angeles, CA)
Histone Deacetylase Inhibitors as a Novel Approach to Combination Chemotherapy in Colon Cancer

Donn C. Young, Ph.D.
Comprehensive Cancer Center
The Ohio State University
(Columbus, OH)
Evaluating the Genetics and Pharmacodynamics of EGFR Blockade in African Americans with Lung Cancer 2005 JVCGC Benefactor Award in honor of Charles Barkley

2004 V Scholar Grants

Iannis Aifantis, Ph.D.
University of Chicago Cancer Research Center
(Chicago, IL)
Pre-T Cell Receptor signaling as a key regulator of acute T cell leukemia
2004 Vintner Grant in honor of Garen and Shari Staglin

Woojin An, Ph.D.
USC/Norris Comprehensive Cancer Center
University of Southern California
(Los Angeles, CA)
Critical role of acetylation and phosphorylation of p53 in cofactor recruitment and transcriptional activation

James E. Bear, Ph.D.
UNC Lineberger Comprehensive Cancer Center
University of North Carolina at Chapel Hill
(Chapel Hill, NC)
The role of Coronins in actin-based cell motility and metastasis
In honor of Frank McCann

Marcia S. Brose, M.D., Ph.D.
Abramson Cancer Center
University of Pennsylvania
(Philadelphia, PA)
The emerging role of genetic analysis in the diagnosis and treatment of thyroid cancer

Andrew B. Herr, Ph.D.
University of Cincinnati
(Cincinnati, OH)
Structure-based design of an anti-tumor antibody to activate multiple immune pathways

Xuejun Jiang, Ph.D.
Memorial Sloan-Kettering Cancer Center
(New York, NY)
Investigation of a novel cell death regulatory pathway

Elizabeth R. Lawlor, M.D., Ph.D., FRCPD
Children's Hospital Los Angeles
(Los Angeles, CA)
Effects of EWS/FlI-1Expression on the Developing Neural Crest: A Novel Model of Ewing’s Sarcoma Tumorigenesis

Susan E. Lyons, M.D., Ph.D.
University of Michigan Comprehensive Cancer Center
University of Michigan
(Ann Arbor, MI)
Discovery of genes required for myeloid development using a zebrafish model

Amy E. Pasquinelli, Ph.D.
Rebecca and John Moores UCSD Cancer Center
University of California, San Diego
(San Diego, CA)
Expression of microRNAs and cancer
In honor of Andrew and Julie Constantin

Jeffrey C. Rathmell, Ph.D.
Duke Comprehensive Cancer Center
Duke University Medical Center
(Durham, NC)
Cell survival and glucose uptake in cancer and autoimmunity
2004 JVCGC Volunteer Grant in honor of Bruce and Susie Foster

Sarah Rice, Ph.D.
Robert H. Lurie Comprehensive Cancer Center
Northwestern University
(Chicago, IL)
A potential general regulator for kinesin motors

Sansana Sawasdikosol, Ph.D.
NYU Cancer Institute
New York University Medical Center
(New York, NY)
The role of prostaglandin E2 and HPK1 in tumor-mediated immune suppression

Loren D. Walensky, M.D., Ph.D.
Dana-Farber/Harvard Cancer Center
Dana-Farber Cancer Institute
(Boston, MA)
Targeting cell death pathways in cancer using hydrocarbon-stapled helices

Yong Wan, Ph.D.
University of Pittsburgh Cancer Institute
(Pittsburgh, PA)
Role of the ubiquitin-proteasome system in genomic integrity and tumor formation

Michael L. Whitfield, Ph.D.
Norris Cotton Cancer Center
Dartmouth-Hitchcock Medical Center
(Hanover, NH)
Genome-wide programs of cell growth and division

2004 Designated Grants

Winship Cancer Institute and Georgia Institute of Technology
Winship Cancer Institute and Georgia Institute of
(Atlanta, GA)
Wallace H. Coulter Department of Biomedical Engineering
Funded by the Atlanta Friends of V

University of Pittsburgh Cancer Institute
(Pittsburgh, PA)
Funded by Show Your Spirit

Roswell Park Cancer Institute
(Buffalo, NY)
Funded by Show Your Spirit Program

Salvatore Bertolone, M.D.
Kosair Children’s Hospital
(Louisville, KY)
Funded by The Louisville Friends of V

James S. Economu, M.D., Ph.D.
Jonsson Comprehensive Cancer Center
University of California, Los Angeles
(Los Angeles, CA)
Emerging Therapies in Colon Cancer
Funded by ESPN, Inc., and the Los Angeles Lakers

Joel Levine, M.D.
Carole and Ray Neag Comprehensive Cancer Center
University of Connecticut Health Center
(Farmington, CT)
Early Diagnosis and Prevention of Colon Cancer in High Risk Patients
Yetta Simon Memorial Grant funded by Marketing Research Consultants

Mokenge P. Malafa, M.D.
H. Lee Moffitt Cancer Center and Research Institute
University of South Florida
(Tampa, FL)
Targeting EGFR Dependent Human Pancreatic Cancer
Funded by the Tampa Friends of V in memory of Paul Majersky

Carolyn Sartor, M.D.
UNC Lineberger Comprehensive Cancer Center
University of North Carolina at Chapel Hill
(Chapel Hill, NC)
Funded by the 2003 Jimmy V Women’s Basketball Classic

Gregory Smith, M.D.
St. Helena Hospital
(St. Helena, CA)
Funded by the Wine Celebration

Walter Stadler, M.D.
University of Chicago
Pritzker School of Medicine
(Chicago, IL)
Investigating antiangiogenic drugs in the treatment of prostate cancer through dynamic contrast-enhanced Magnetic Resonance Imaging (MRI) techniques
Funded by the Windy City Golf Classic in memory of Michael Klein

2004 Translational Grants

Kellie Archer, Ph.D.
Harry D. Bear, M.D., Ph.D.
Catherine Isabelle Dumur, Ph.D.
Carleton T. Garrett, M.D., Ph.D.
Peter O'Connell, Ph.D.
Massey Cancer Center
Virginia Commonwealth University
(Richmond, VA)
Tumor Genetic Profiling: New predictive assays for breast cancer therapy

Daphne Bell, Ph.D.
Daniel Haber, M.D., Ph.D.
Eunice Kwak, M.D., Ph.D.
Thomas Lynch, M.D.
Jeffrey E. Settleman, Ph.D.
Raffaella Sordella, Ph.D.
Massachusetts General Hospital Cancer Center
(Boston, MA)
Mechanism of acquired resistance to Iressa in non-small cell lung cancer
In memory of Christopher T. Carroll

John Byrd, M.D.
Ching-Shih Chen, Ph.D.
Michael Freitas, Ph.D.
Michael Grever, Ph.D.
Samual Kulp, Ph.D.
David Lucas, Ph.D.
Mark R. Parthun, Ph.D.
Amy Sklenar, B.S.
Xiaodan Su, Ph.D.
Comprehensive Cancer Center
The Ohio State University
(Columbus, OH)
Chromatin regulation as a therapeutic target to enhance biologic therapies in Chronic Lymphocytic Leukemia (CLL)
Partially funded by Cardinal Health

John M. Chirgwin, Ph.D.
Theresa A. Guise, M.D.
Michelle Heine, R.N, M.S.
Aileen Heras-Herzig, M.D.
Wende M. Kozlow, M.D.
Richard Santen, M.D.
UVA Cancer Center
University of Virginia, Health Sciences Center
(Charlottesville, VA)
Effects of a high bone turnover state induced by estrogen deficiency on the development and progression of breast cancer and bone metastases
2004 JVCGC Benefactor Grant in honor of GlaxoSmithKline

2003 V Scholar Grants

Gerard C. Blobe, M.D., Ph.D.
Duke Comprehensive Cancer Center
Duke University Medical Center
(Durham, NC)
Title Identification of Mechanisms for TGF-β Resistance and for the Dichotomous Function of TGF-β in Mammary Carcinogenesis

Anjen Chenn, M.D., Ph.D.
Robert H. Lurie Comprehensive Cancer Center
Northwestern University
(Chicago, IL)
Mechanisms of Beta Catenin in Cancer and Brain Development

Ramana Davuluri, Ph.D.
Comprehensive Cancer Center
The Ohio State University
(Columbus, OH)
Computational approaches to explore transcriptional regulation in hematopoiesis and leukemia

James DiRenzo, Ph.D.
Norris Cotton Cancer Center
Dartmouth-Hitchcock Medical School
(Lebanon, NH)
Transcriptional Control of Multi-potency in Mammary Epithelia

Lawrence Fong, M.D.
UCSF Comprehensive Cancer Center & Cancer Research Institute
University of California, San Francisco
(San Francisco, CA)
Induction and Characterization of Tumor-Specific T cells in vivo Funded by The V Foundation Wine Celebration

Douglas K. Graham, M.D., Ph.D.
University of Colorado Cancer Center
University of Colorado at Denver & Health Sciences
(Denver, CO)
Use of transgenic mouse models to define a potential role of the proto-oncogene mer in pediatric acute lymphocytic leukemia

Prasad V. Jallepalli, M.D., Ph.D.
Memorial Sloan-Kettering Cancer Center
(New York, NY)
Targeting chromosomal instability for cancer therapy In honor of Frank Cannata

Deanna M. Koepp, Ph.D.
University of Minnesota Cancer Center
(Minneapolis, MN)
The Rote of SCF Ubiquitin Ligases in Cyclin E Proteolysis

Shaoguang Li, M.D., Ph.D.
The Jackson Laboratory Cancer Center
(Bar Harbor, ME)
Genetic identification of key signaling molecules that have therapeutic potential for treating more advanced leukemias induced by the BCR/ABL oncogene

Ben Ho Park, M.D., Ph.D.
Sidney Kimmel Comprehensive Cancer Center
at Johns Hopkins University
(Baltimore, MD)
Understanding BRCA-1 Function by Targeted Gene Disruption in a Somatic Normal Breast Ipithelial Cell Line
Funded by the NFL Referees Association in honor of their wives and mothers

W. Kimryn Rathmell, M.D., Ph.D.
UNC Lineberger Comprehensive Cancer Center
University of North Carolina at Chapel Hill
(Chapel Hill, NC)
Functional effects of von Hippel-Lindau gene mutations in tumorigenesis JVCGC Volunteer Grant in Memory of John Geddes

Maria S. Soengas, Ph.D.
Univeristy of Michigan Comprehensive Cancer Center
University of Michigan
(Ann Arbor, MI)
Inactivation of Apoptosis in Melanoma Progression and Drug Resistance

Götz-Ulrich von Bülow, Ph.D.
Indiana University Melvin and Bren Simon Cancer Center
(Indianapolis, IN)
Validation of a role for TACI in prostate neoplasia

Lin Zhang, Ph.D.
University of Pittsburgh Cancer Institute
(Pittsburgh, PA)
Defects in apoptotic machinery and altered response to anticancer agents in human cancer cells

Sandra S. Zinkel, M.D., Ph.D.
Dana-Farber/Harvard Cancer Center
Dana-Farber Cancer Institute
(Boston, MA)
Bid Function in Myeloid Homeostasis and Leukemogenesis

2003 Designated Grants

UCSF Comprehensive Cancer Center & Cancer Research Institute
University of California, San Francisco
(San Francisco, CA)
Joan Rombauer Endowed Fellowship in Pancreatic Cancer Research

Larry K. Kvols, M.D.
H. Lee Moffitt Cancer Center and Research Institute
University of South Florida
(Tampa, FL)
JVCGC Benefactor Grant in Honor of Gary Romp

Arnold J. Levine, Ph.D.
The Cancer Institute of New Jersey
Robert Wood Johnson Medical School
(New Brunswick, NJ)
Molecular Profiling of Carcinoma of Unknown Primary Funded by UNICO International in memory of James Mattiace

Cheryl London, DVM, Ph.D.
UC Davis Cancer Center
University of California, Davis
(Sacramento, CA)
2003 Vintner Grant in Honor of Marc Beringer

Ravi Salgia, M.D., Ph.D.
University of Chicago
Pritzker School of Medicine
(Chicago, IL)
Guy Geleerd Memorial Research Grant

2003 Translational Grants

Diane M. Da Silva, Ph.D.
W. Martin Kast, Ph.D.
I. Caroline Le Poole, Ph.D.
Laila Muderspach, M.D.
Jeffrey S. Weber, M.D., Ph.D.
USC/Norris Comprehensive Cancer Center
University of Southern California
(Los Angeles, CA)
A New Approach for Dendritic Cell-Based Cancer Immunotheraphy for Cervical Cancer

Paul Dent, Ph.D.
Steven Grant, M.D.
John Roberts, M.D.
Massey Cancer Center
Virginia Commonwealth University
(Richmond, VA)
Combined Proteasome and Cyclin-Dependent Kinase Inhibition: A Novel Therapeutic Strategy in Hematologic Malignancies

Amar Gajjar, M.D.
Richard J. Gilbertson, M.D., Ph.D.
Helen Poppleton, Ph.D.
St. Jude Children's Research Hospital
(Memphis, TN)
The Role of ERBB2 signaling in Pediatric Medulloblastoma

2002 V Scholar Grants

Ricardo C.T. Aguiar, M.D., Ph.D.,
Dana-Farber/Harvard Cancer Center
Dana-Farber Cancer Institute
(Boston, MA)
Validate the Potential Role of a Gene Named PDE4B in the Development and Progression of Diffuse Large B-cell Lymphoma (DLB-CL)

Gabriele Bergers, Ph.D.,
UCSF Comprehensive Cancer Center & Cancer Research Institute
University of California, San Francisco
(San Francisco, CA)
Identification of Mechanisms and Factors Implicated in Angiogenesis During Development and Progression of the Highly Vascularized Cancers of the Pancreas and Brain Funded by The V Foundation Wine Celebration

Fred Bunz, M.D., Ph.D.,
Sydney Kimmel Comprehensive Cancer Center
at Johns Hopkins University
(Baltimore, MD)
Genetic Determinants of Therapeutic Sensitivity in Colon Cancer Cells: the Role of Inhibitor of Apoptosis Proteins in the Theraputic Sensitivity of Tumor Cells

Arul M. Chinnaiyan, M.D., Ph.D.,
University of Michigan Comprehensive Cancer Center
University of Michigan
(Ann Arbor, MI)
Transcriptome Analysis of Breast and Prostate Cancer Reveals Connections to Fatty Acid Metabolism

Frank B. Furnari, Ph.D.,
Rebecca and John Moores UCSD Cancer Center
University of California, San Diego
(San Diego, CA)
Analysis of Receptor Tyrosine Kinase Signaling Impingement on PTEN Function in Glioma

Denis C. Guttridge, Ph.D.,
Comprehensive Cancer Center
The Ohio State University
(Columbus, OH)
Cancer Cachexia, A Debilitating Metabolic Disorder Characterized by Extreme Muscle Wasting

Joseph G. Hacia, Ph.D.,
USC/Norris Comprehensive Cancer Center
University of Southern California
(Los Angeles, CA)
Molecular Characterization of Aids-related Lymphomas

Jan Karlseder, Ph.D.,
Salk Institute Cancer Center
Salk Institute
(La Jolla, CA)
Differences Between Primary Cells and Tumor Cells, in Regard to the Mechanism of Chromosome End Protection

Ralf Landgraf, Ph.D.,
Jonsson Comprehensive Cancer Center
University of California, Los Angeles
(Los Angeles, CA)
Ligand-independent Self-association of HER2 and HER3 Receptors: Identification of Responsible Protein Interfaces and Their Contribution to Cellular Transformation in HER2

Jason D. Lieb, Ph.D.
UNC Lineberger Comprehensive Cancer Center
University of North Carolina at Chapel Hill
(Chapel Hill, NC)
Understanding Specificity and Function in Protein-Genome Interactions

Kay Macleod, Ph.D.,
University of Chicago Cancer Research Center
(Chicago, IL)
Understanding the Functions of Novel Forms of the Rb Tumor Suppressor in Human Cancer

Robert A. Marciniak, M.D., Ph.D.,
San Antonio Cancer Institute
University of Texas Health Science Center at San A
(San Antonio, TX)
ALT Telomere Maintenance Mechanisms and the Proteins Involved in ALT Telomere Maintenance.

Senthil K. Muthuswamy, Ph.D.,
Cold Spring Harbor Laboratory
(Cold Spring Harbor, NY)
Molecular Mechanisms by which ErbB Receptors Initiate Breast Cancer

Man-Wah Tan, Ph.D.,
Stanford University School of Medicine
(Stanford, CA)
Identification and Characterization of Novel Components in TGF-beta Signaling Funded by The V Foundation Wine Celebration

Valeri Vasioukhin, Ph.D.,
Fred Hutchinson/University of Washington Cancer Consortium
Fred Hutchinson Cancer Research Center
(Seattle, WA)
The Functional Role of Serine Protease Hepsin in Prostate Cancer.

Robert H. Vonderheide, M.D., D. Phil.,
Abramson Cancer Center
University of Pennsylvania
(Philadelphia, PA)
Evaluation of T helper cell epitopes derived from the universal tumor antigen telomerase.

Jennifer Westendorf, Ph.D.,
University of Minnesota Cancer Center
(Minneapolis, MN)
Deregulated Runx2 Activity in Cancer-Associated Bone Disease.

2002 Designated Grants

Queen of the Valley Hospital
V Foundation Cancer Rehabilitation Center
(Napa Valley, CA)
Funded by The V Foundation Wine Celebration

Peter Albertsen, M.D.
Pamela Taxel, M.D.
Carole and Ray Neag Comprehensive Cancer Center
University of Connecticut Health Center
(Farmington, CT)
The potential role of Estrogen on the Inhibition of both Osteoclastogenesis and Skeletal Metastasis formation in Men with Prostate Cancer. Funded by UNICO International in memory of Leo Diana

Lynne Bemis, Ph.D.
University of Colorado Cancer Center
University of Colorado at Denver & Health Sciences
(Denver, CO)
The development and Introduction of Rational, Molecular Based Therapy for Human Malignant Melanoma Vintner Grant in Honor of Arlene Cosentino Funded by The V Foundation Wine Celebration

Andrew Krivoshik, M.D., Ph.D.,
Duke Children's Hospital and Health Center
(Durham, NC)
Funded by The Jimmy V Celebrity Junior Golf Classic
The Jim Valvano Post-Doctoral Fellowship in Pediatric Cancer Research

Paul Meyers, M.D.
Memorial Sloan-Kettering Cancer Center
(New York, NY)
Funded in Memory of Todd Bucher

Victoria Seewaldt, M.D.
Duke Comprehensive Cancer Center
Duke University Medical Center
(Durham, NC)
Funded by the Jimmy V Women's Basketball Classic
Research-focused breast cancer chemoprevention clinic.

2002 Translational Grants

Linzhao Cheng, Ph.D.
Hyam I. Levitsky, M.D.,
Martin G. Pomper, M.D. ,Ph.D.
Richard Wahl, M.D.,
Sidney Kimmel Comprehensive Cancer Center
at Johns Hopkins University
(Baltimore, MD)
In Vivo Imaging for Hematopoietic Cell Therapies

James M. Ford, M.D.,
Sylvia Plevritis, Ph.D.,
Stanford University School of Medicine
(Stanford, CA)
Determinants of Genomic Instability in Women with BRCA1 Mutations Undergoing Comprehensive Breast Cancer Screening Funded in Honor of Joan and Koerner Rombauer

Greg Otterson, M.D.,
Christoph Plass, Ph.D.,
Ming You, M.D., Ph.D.,
Comprehensive Cancer Center
The Ohio State University
(Columbus, OH)
Methylation as a Therapeutic Target in Lung Cancer

2001 V Scholar Grants

Steven Artandi, M.D., Ph.D.
Stanford University School of Medicine
(Palo Alto, CA)
Telomerase in breast development and breast cancer

John D. Crispino, Ph.D.
University of Chicago Cancer Research Center
(Chicago, IL)
Characterization of Angiogenic Transcription Factors

Blossom Damania, Ph.D.
UNC Lineberger Comprehensive Cancer Center
University of North Carolina at Chapel Hill
(Chapel Hill, NC)
Understanding the role of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in the etiology of human cancer

Alexander L. Dent, Ph.D.
Indiana University Melvin and Bren Simon Cancer Center
(Indianapolis, IN)
Regulation of C-Jun/Ap-1 Activity by the BCL-6 Pro2 oncogene

Laura A. Johnston, Ph.D.
Herbert Irving Comprehensive Cancer Center
College of Physicians & Surgeons Columbia Universi
(New York, NY)
A determination of how the Wingless/Wnt signal regulates growth in an intact, growing organism

Weiquin Li, M.D.
Lombardi Comprehensive Cancer Center
Georgetown University
(Washington, DC)
Induction of Apoptosis by Activation of Protein Kinase C-delta in Abl-Induced Hematopoietic Malignancies

Lawrence C. Meyers, Ph.D.
Norris Cotton Cancer Center
Dartmouth-Hitchcock Medical School
(Lebanon, NH)
Mechanisms of Eukaryotic Transcriptional Repression

Kornelia Polyak, M.D., Ph.D.v
Dana-Farber/Harvard Cancer Center
Dana-Farber Cancer Institute
(Boston, MA)
Identification and characterization a receptor for the HIN-1 novel putative breast tumor suppressor gene

Jonathan D. Powell, M.D., Ph.D.
Sidney Kimmel Comprehensive Cancer Center
at Johns Hopkins University
(Baltimore , MD)
Indentification of novel T cell receptor induced genes as targets to enhance tumor immunity

Karen Vasquez, Ph.D.
MD Anderson Cancer Center
University of Texas
(Houston, TX)
Inhibition of DNA Repair by High Mobility Group Protiens

Zhuohua Zhang, Ph.D.
The Burnham Institute
(La Jolla, CA)
APC Signaling in Tumorigenesis

2001 Designated Grants

Jeffrey Axelrod, M.D., Ph.D.
Stanford University School of Medicine
(Palo Alto, CA)
Funded by The V Foundation Wine Celebration

Emily K. Bergsland, M.D.
UCSF Comprehensive Cancer Center & Cancer Research Institute
University of California, San Francisco
(San Francisco, CA)
Funded by The V Foundation Wine Celebration In Honor of Joan Rombaur

Suzanne K. Conzen, M.D.
University of Chicago Cancer Research Center
(Chicago, IL)
Funded by UNICO International in memory of Madelyn Fornelli

Calvin Kuo, M.D., Ph.D.
Stanford University School of Medicine
(Palo Alto, CA)
Funded by The V Foundation Wine Celebration

Katherine Matthay, M.D.
UCSF Comprehensive Cancer Center & Cancer Research Institute
University of California, San Francisco
(San Francisco, CA)
Funded by The V Foundation Wine Celebration In Honor of Dick Grace and Jason Ferrick

Martin McMahon, Ph.D.
UCSF Comprehensive Cancer Center & Cancer Research Institute
University of California, San Francisco
(San Francisco, CA)
Funded by The V Foundation Wine Celebration In Honor of Joan Rombaur

Dimitar Nikolov, Ph.D.
Memorial Sloan-Kettering Cancer Center
(New York, NY)
Funded by Cannata Marketing and Konica In memory of Cyrus R. Tyler

2001 Translational Grants

Wadih Arap, M.D., Ph.D.
Renata Pasqualini, Ph.D.
MD Anderson Cancer Center
University of Texas
(Houston, TX)
Translation of the Molecular Diversity of Blood Vessels into Vascular Targeting Applications

Ronald A. DePinho, M.D.
Elizabeth Anne Maher, M.D., Ph.D.
Dana-Farber/Harvard Cancer Center
Dana-Farber Cancer Institute
(Boston, MA)
In honor of ESPN.
EGFR Signaling in the Maintenance of Glioblastoma in Mice and Men

Charis Eng, M.D., Ph.D.
Gustavo Leone, Ph.D.
Michael Ostrowski, Ph.D.
Comprehensive Cancer Center
The Ohio State University
(Columbus, OH)
Funded by the Jimmy V Celebrity Golf Classic
Genetic Analysis of the Role of the Microenvironment in Breast Tumor Progression

2000 V Scholar Grants

Maria-Luisa Alegre, M.D., Ph.D.
University of Chicago Cancer Research Center
(Chicago, IL)
CD3: Signaling in T Lymphocytes and Role in Tumor Rejection

Dominique Broccoli, Ph.D
Fox Chase Cancer Center
(Philadelphia, PA)
Elucidating the signaling molecules and molecular mechanisms by which telomeres limit proliferation

Lisa M. Coussens, Ph.D.
UCSF Comprehensive Cancer Center & Cancer Research Institute
University of California, San Francisco
(San Francisco, CA)
Gelatinase B and Epithelial Cancer Development

J. Alan Diehl, Ph.D.
University of Nebraska Medical Center/Eppley Cancer Center
(Omaha, NE)
Determination of the oncogenic potential of a novel cyclin D1 mutant

Dean W. Felsher, M.D., Ph.D.
Stanford University School of Medicine
(Stanford, CA)
The Role of the MYC Proto-Oncogene in the Initiation and Maintenance of Tumorigenesis

Thomas M. Guadagno, Ph.D.
H. Lee Moffitt Cancer Center and Research Institute
University of South Florida
(Tampa, FL)
Elucidate the role of MAP kinase in regulating the events of mitosis

Masaaki Hamaguchi, M.D., Ph.D.
Cold Spring Harbor Laboratory
(Cold Spring Harbor, NY)
Genetic analysis of Cancer and its application to the discovery of tumor suppressor genes involved in breast cancer

Shawn E. Holt, Ph.D
Massey Cancer Center
Virginia Commonwealth University
(Richmond, VA)
Research and Rationale for the role of Telmerase in Human Cancer Development

Stuart Lutzker, M.D., Ph.D.
The Cancer Institute of New Jersey
Robert Wood Johnson Medical School
(New Brunswick, NJ)
To determine the role of N- and C- terminal amino acid modifications in regulating p53 activity in vivo

Steven B. McMahon, Ph.D.
The Wistar Institute
(Philadelphia, PA)
The role of the c-myc Oncogene in Human Cancer

Nickolas Papadopoulos, Ph.D.
Herbert Irving Comprehensive Cancer Center
College of Physicians & Surgeons Columbia Universi
(New York, NY)
Identification of Androgen Receptor Regulated Genes: New Targets of Intervention in advanced disease

Jill M. Schumacher, Ph.D.
MD Anderson Cancer Center
University of Texas
(Houston, TX)
Research on the genetics of chromosome segregation and cytokinesis, using C. elegans

Victoria Seewaldt, M.D.
Duke Comprehensive Cancer Center
Duke University Medical Center
(Durham, NC)
Tamoxifen-mediated apoptosis: a model of chemoprevention

Jeffrey R. Smith, M.D., Ph.D.
Vanderbilt-Ingram Cancer Center
Vanderbilt University
(Nashville, TN)
Molecular Genetics of Hereditary Prostate Cancer

Marcel R. M. van den Brink, M.D., Ph.D.
Memorial Sloan-Kettering Cancer Center
(New York, NY)
Murine bone marrow transplantation models for graft-versus-tumor, graft-versus-host-disease, and posttransplant immune reconstitution

Yi Zhang, Ph.D.
UNC Lineberger Comprehensive Cancer Center
University of North Carolina at Chapel Hill
(Chapel Hill, NC)
Understanding NuRD Function through Targeted Deletion of MTA2 in Mouse

2000 Designated Grants

Laura Attardi, Ph.D.
Stanford University School of Medicine
(Palo Alto, CA)
Funded by The V Foundation Wine Celebration

Grover Bagby, M.D.
OHSU Cancer Institute
Oregon Health & Science University
(Portland, OR)
Funded by Papa John’s International

Thomas Beck, M.D.
St. Luke’s Regional Medical Center
(Boise, ID)
Funded by Papa John’s International

Salvatore Bertoline, M.D.
Kosair Children’s Hospital
(Louisville, KY)
Funded by Papa John’s International

Timothy Bolek, M.D.
Tallahassee Memorial Health Care
(Tallahassee, FL)
Funded by Papa John’s International

Chad Brands, M.D.
Children’s Medical Center of Dayton
(Dayton, OH)
Funded by Papa John’s International

William Butler, M.D.
South Carolina Comprehensive Breast Center
Palmetto Health
(Columbia, SC)
Funded by Papa John’s International

Vincent DeVita, M.D.
Yale Cancer Center
Yale University School of Medicine
(New Haven, CT)
Funded by UNICO International In Memory of Louis Dante Jr.

Timothy Eberlein, M.D.
Siteman Cancer Center
Washington University School of Medicine
(St. Louis, MO)
Funded by Papa John’s International

Jason Fleming, M.D.
University of Texas Southwestern Medical Center
(Dallas, TX)
Funded by Papa John’s International

Ted Ganiats, M.D.
Carolyn Ross, M.D., M.P.H.
Rebecca and John Moores UCSD Cancer Center
University of California, San Diego
(La Jolla, CA)
Funded by The V Foundation Wine Celebration Vintner's Grant In memory of Ren Harris

Edward Hirschowitz, M.D.
Markey Cancer Center
Kentucky, University of
(Lexington, KY)
Funded by Papa John’s International

Ann Hoff, M.A.
Carilion Cancer Center
(Roanoke, VA)
Funded by Papa John’s International

David Jones, M.D.
Huntsman Cancer Institute
University of Utah
(Salt Lake City, UT)
Funded by Papa John’s International

Robert Jotte, M.D., Ph.D.
University of Colorado Cancer Center
University of Colorado at Denver & Health Sciences
(Denver, CO)
Funded by Papa John’s International

Ralf Krahe, Ph.D.
Comprehensive Cancer Center
The Ohio State University
(Columbus, OH)
Funded by Papa John’s International

Quynh-Thu Le, M.D.
Stanford University School of Medicine
(Palo Alto, CA)
Funded by The V Foundation Wine Celebration

Brian Link, M.D.
Holden Comprehensive Cancer Center
University of Iowa
(Iowa City, IA)
Funded by Papa John’s International

Sharon Lockhart, M.D.
Children’s Hospital of Austin
(Austin, TX)
Funded by Papa John’s International

Sagar Lonialc, M.D.
Winship Cancer Institute
Emory University
(Atlanta, GA)
Funded by Papa John’s International

Aly Mageed, M.D.
Children's Medical Center of Dayton
(Youngstown, OH)

James Louis McGee, M.D.
St. Francis Medical Center
(Peoria, IL)
Funded by Papa John’s International

Thomas McLean, M.D.
Wake Forest Comprehensive Cancer Center
Wake Forest University
(Winston-Salem, NC)
Funded by Papa John’s International

Mike Moore, Ph.D.
Marshall University School of Medicine
(Huntington, WV)
Funded by Papa John’s International

Cheppail Ramachandran, Ph.D.
Miami Children’s Hospital
(Miami, FL)
Funded by Papa John’s International

Rolf Reene, Ph.D.
Case Comprehensive Cancer Center
Case Western Reserve University
(Cleveland, OH)
Funded by Papa John’s International

M. Patricia Riveria, M.D.
UNC Lineberger Comprehensive Cancer Center
University of North Carolina at Chapel Hill
(Chapel Hill, NC)
Funded by Papa John’s International

Leslie Robison, Ph.D.
University of Minnesota Cancer Center
(Minneapolis, MN)
Funded by Papa John’s International

Charles Rudin, M.D., Ph.D.
University of Chicago Cancer Research Center
(Chicago, IL)
In memory of Guy Geleerd

Daitoku Sakamuro,, Ph.D.
Purdue University Cancer Center
(West Lafayette, IN)
Funded by Papa John’s International

Anke Schulte, Ph.D.
Lombardi Comprehensive Cancer Center
Georgetown University
(Washington, DC)
Funded by Papa John’s International

Andrew E. Sloan, M.D.
The Barbara Ann Karmanos Cancer Institute
Wayne State University School of Medicine
(Detroit, MI)
Funded by Papa John’s International

Peter S. Turk, M.D.
Presbyterian Cancer Center
(Charlotte, NC)
Funded by Papa John’s International

Joe Vaccaro, Ph.D.
Tulane Cancer Center
(New Orleans, LA)
Funded by Papa John’s International

Daniel Von Hoff, M.D.
Arizona Cancer Center, University of
(Tucson, AZ)
Funded by Papa John’s International

Max Wicha, M.D.
University of Michigan Comprehensive Cancer Center
University of Michigan
(Ann Arbor, MI)
Funded by Papa John’s International

David Williams, M.D.
Riley Hospital for Children
(Indianapolis, IN)
Funded by Papa John’s International

Cheryl Willman, M.D.
University of New Mexico Cancer Research & Treatment Center
University of New Mexico
(Albuquerque, NM)
Funded by Papa John’s International

John Wingard, M.D.
University of Florida Shands Cancer Center
(Gainesville, FL)
Funded by Papa John’s International

Jeff Yoder, M.D.
Parkview Stucky Research Center
(Ft. Wayne, IN)
Funded by Papa John’s International

Cynthia Zahnow, M.D.
Sidney Kimmel Comprehensive Cancer Center
at Johns Hopkins University
(New York, NY)
Funded by Papa John’s International

Cynthia Zahnow, M.D.
Sidney Kimmel Comprehensive Cancer Center
at Johns Hopkins University
(Baltimore, MD)

William Zamboni, M.D.
University of Pittsburgh Cancer Institute
(Pittsburgh, PA)
Funded by Papa John’s International

1999 V Scholar Grants

Peter D. Adams, Ph.D.
Fox Chase Cancer Center
(Philadelphia, PA)
Studying how HIRA is a key regulator in the DNA Replication Process

Carrolee Barlow, M.D., Ph.D.
Salk Institute Cancer Center
Salk Institute
(La Jolla, CA)
Studying the Basis of Human Hematolymphopoietic Malignancies, using a mouse model of human Ataxia-Telangiectasia

Phang-Lang Chen, Ph.D.
San Antonio Cancer Institute
University of Texas Health Science Center at San A
(San Antonio, TX)
The BRCA genes, the DNA repair machiner and cancer

Chin Chiang, Ph.D.
Vanderbilt-Ingram Cancer Center
Vanderbilt University
(Nashville, TN)
Control of Sonic Hedgehog (Shh) Activity and Signaling

Lynda Chin, M.D.
Dana-Farber/Harvard Cancer Center
Dana-Farber Cancer Institute
(Boston, MA)
Exploration of the roles of RAS, INK4a, and p53 in the genesis, maintenance and progression of melanoma

Christopher Counter, Ph.D.
Duke Comprehensive Cancer Center
Duke University Medical Center
(Durham, NC)
Characterization of the Telomerase Catalytic Subhunt hTERT

Nam Hoang Dang, M.D., Ph.D.
MD Anderson Cancer Center
University of Texas
(Houston, TX)

James M. Ford, M.D.
Stanford University School of Medicine
(Stanford, CA)
Molecular Determinants of Drug Sensitivity in GI Cancers

Christoph Lengauer, Ph.D.
Sidney Kimmel Comprehensive Cancer Center
at Johns Hopkins University
(Baltimore, MD)
Identification of Genes that cause Chromosomal instability in Human Cancers

Gustavo W. Leone, Ph.D.
Comprehensive Cancer Center
The Ohio State University
(Columbus, OH)
The Role of the E2F3 Gene Locus in the Control of Proliferation and Tumorigenesis

Thomas Ludwig, Ph.D.
Herbert Irving Comprehensive Cancer Center
College of Physicians & Surgeons Columbia Universi
(New York, NY)
Targeted mutation of the p53 tumor suppressor gene in the mammary gland of the mouse. A potential animal model for the Li-Fraumeni syndrome

Michael P. Myers, Ph.D.
Cold Spring Harbor Laboratory
(Cold Spring Harbor, NY)
The function of PTEN and inositol phospholipid-dependent signals in tumorigenesis

Ramin Shiekhattar, Ph.D.
The Wistar Institute
(Philadelphia, PA)
Biochemical Analysis of the Role of the BRCA2 Complex in the Development of Breast Cancer

Todd Waldman, M.D., Ph.D.
Lombardi Comphrensive Cancer Center
Georgetown University
(Washington, DC)
Study of the PTEN Tumor Suppressor Gene by Targeted Deletion in Human Cancer Cells

Ebrahim Zandi, Ph.D.
USC/Norris Comprehensive Cancer Center
University of Southern California
(Los Angeles, CA)
Anti-apoptotic function of NF-kB and its Signaling in Cancer

1999 Designated Grants

Mark W. Geraci, M.D.
University of Colorado Cancer Center
University of Colorado at Denver & Health Sciences
(Denver, CO)
Funded by Papa John's International, Inc.

Peter Lee, M.D.
Stanford University School of Medicine
(Palo Alto, CA)
Funded by The V Foundation Wine Celebration

Paul Meyers, M.D.
Memorial Sloan-Kettering Cancer Center
(New York, NY)
Funded in Memory of Todd Bucher

Gillian Sanders, Ph.D.
Stanford University School of Medicine
(Palo Alto, CA)
Funded by The V Foundation Wine Celebration

Peter S. Turk, M.D.
Presbyterian Cancer Center
(Charlotte, NC)
Funded by Papa John's International, Inc.

Wendel Wenneker, M.D.
Queen of the Valley Hospital
(Napa Valley, CA)
Funded by The V Foundation Wine Celebration

1998 V Scholar Grants

Atul Bedi, M.D.
Sidney Kimmel Comprehensive Cancer Center
at Johns Hopkins University
(Baltimore, MD)
Role of p53-mediated repression of Nf-kB RelA in DNA damage-induced apoptosis

Peter Brooks, Ph.D.
USC/Norris Comprehensive Cancer Center
University of Southern California
(Los Angeles, CA)
Expression and Regulation of the C-Terminal AntiAngiogenic Fragment of MMP-2: Role in Breast Tumor Growth and Angiogenesis

William E. Carson, M.D.
Comprehensive Cancer Center
The Ohio State University
(Columbus, OH)
Interferon-alpha-Induced Activation of STAT Proteins in Milignant Melanoma¹

Thomas R. Coleman, Ph.D.
Fox Chase Cancer Center
(Philadelphia, PA)
Characterization of Cdc6 protein in DNA Replication and Cell Cycle Progression

Andrew Futreal, Ph.D.
Duke Comprehensive Cancer Center
Duke University Medical Center
(Durham, NC)
Genetic susceptibility to hereditary Breast and Ovarian Cancer

James Koh, Ph.D.
Vermont Cancer Center
University of Vermont
(Burlington, VT)
Role of the tumor suppressor protein p16 in the development of glioblastoma multiforme

Dimitar Nikolov, Ph.D.
Memorial Sloan-Kettering Cancer Center
(New York, NY)
Structural Studies of Deleted in Colorectal Cancer/Netrin Signal Transduction System

Charles Rudin, M.D., Ph.D.
University of Chicago Cancer Research Center
(Chicago, IL)
The Role of apoptotic inhibition in squamous cell carcinogenesis

Ke Shuai, Ph.D.
Jonsson Comprehensive Cancer Center
University of California, Los Angeles
(Los Angeles, CA)
Negative Regulation of Cytokine Signaling by PIAS Proteins

Yan A Su, C.M.D., Ph.D.
Lombardi Comprehensive Cancer Center
Georgetown University
(Washington, DC)
Large Scale Analysis of Genes Involved in Breast Cancer Progression by Insertional Mutagenesis and cDna Microarrays

Charles Theuer, M.D.
Chao Family Comprehensive Cancer Center
University of California at Irvine
(Orange, CA)
Use of a Non-Toxic Form of Pseudomonas Exotoxin to Elicit Cellular Immunity to Melanoma

David W. Threadgill, Ph.D.
Vanderbilt-Ingram Cancer Center
Vanderbilt University
(Nashville, TN)
An animal model of hereditary non-polyposis colorectal cancer

Chuanyue Wu, Ph.D.
UAB Comprehensive Cancer Center
University of Alabama at Birmingham
(Birmingham, AL)
The Role of the Integrinlinked Kinase Signaling in Anchorage-independent Cell Growth

1998 Designated Grants

Hipple Cancer Research Center
(Dayton, OH)

1997 V Scholar Grants

John Carethers, M.D.
Rebecca and John Moores UCSD Cancer Center
University of California, San Diego
(La Jolla, CA)
Identification and Characterization of a Tumor Suppressor Gene involved in Juvenile Intestinal Polyposis

James DeGregori, Ph.D.
University of Colorado Cancer Center
University of Colorado at Denver & Health Sciences
(Denver, CO)
The Role of the E2F transcription factors in regulating cell cycle progression

Paul Dent, Ph.D.
Massey Cancer Center
Virginia Commonwealth University
(Richmond, VA)
Signal transduction mechanisms activated by ionizing radiation, and their relationship to proliferative potential

Tatyana Golovkina, Ph.D.
The Jackson Laboratory Cancer Center
(Bar Harbor, ME)
The role of viral superantigens in MMTV-induced mammary gland tumorigenesis

Rafael Herrera, Ph.D.
San Antonio Cancer Institute
University of Texas Health Science Center at San A
(San Antonio, TX)
Phosphorylation of Histone H1 by Cyclin/CDK complexes in cell cycle progression and carcinogenesis

Jin Jen, M.D., Ph.D.
Sidney Kimmel Comprehensive Cancer Center
at Johns Hopkins University
(Baltimore, MD)
Genetic Characterization of Genes involved in Non-small cell Lung cancer

Akiko Shimamura, M.D., Ph.D.
Dana-Farber/Harvard Cancer Center
Dana-Farber Cancer Institute
(Boston, MA)
Cell-Free Analysis of p53 and the Apoptosis Cascade

Linda Van Aelst, Ph.D.
Cold Spring Harbor Laboratory
(Cold Spring Harbor, NY)
Ras and Rac Signaling Pathways involved in Tumorigenisis and Metastasis

Hong Wu, M.D., Ph.D.
Jonsson Comprehensive Cancer Center
University of California, Los Angeles
(Los Angeles, CA)
Molecular and Genetic Study of Erythropoietin Receptor signaling pathways

Hong Yan, Ph.D.
Fox Chase Cancer Center
(Philadelphia, PA)
Function of the FFA-1/Werner's Syndrome Gene Product in the Organization and Replication of Eukaryotic DNA

Elizabeth Yang, M.D., Ph.D.
Vanderbilt-Ingram Cancer Center
Vanderbilt University
(Nashville, TN)
Using BAD/BCL2 and BAD/BCL-XL Interactions to Dissect the Relationship between Apoptosis and Cell Cycle

1997 Designated Grants

Hipple Cancer Research Center
(Dayton, OH)

1996 V Scholar Grants

Powel Brown, M.D., Ph.D.
San Antonio Cancer Institute
University of Texas Health Science Center at San A
(San Antonio, TX)
Role of the AP-1 transcription factor in regulating breast cell growth, invasion, and transformation

Rolf Freter, M.D., Ph.D.
Herbert Irving Comprehensive Cancer Center
College of Physicians & Surgeons Columbia Universi
(New York, NY)
Regulation of transcription of immediate-early genes: Implications for the treatment of cancer

John Gasdaska, M.D.
Arizona Cancer Center, University of
(Tucson, AZ)
Thioredozin and the Control of Cancer Cell Growth

James Herman, M.D.
Sidney Kimmel Comprehensive Cancer Center
at Johns Hopkins University
(Baltimore, MD)
Timing the inactivation of Tumor suppressor and metastasis suppressor genes in human neoplasia

Bo Liu, Ph.D.
University of Pittsburgh Cancer Institute
(Pittsburgh, PA)
Analysis of Mismatch Repair genes in HNPCC

Neil Spector, M.D.
University of Miami
(Miami, FL)
Cellular regulating elements for development of tumor specific therapies

Christopher Weghorst, Ph.D.
Comprehensive Cancer Center
The Ohio State University
(Columbus, OH)
The role of inactivation of the transforming growth factor beta (TGFβ) receptor complex in human breast cancer

1996 Designated Grants

Hipple Cancer Research Center
(Dayton, OH)
Awarded to establish an endowment for their summer scholars program.

Duke Children's Hospital and Health Center
(Durham, NC)
Opened May 2000. Treats children with cancer on an outpatient basis. The hospital will provide services for over 9,000 children per year.

Gerold Bepler, M.D., Ph.D.
Duke Comprehensive Cancer Center
Duke University Medical Center
(Durham, NC)